pattismith
Senior Member
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Losing Our Minds: How Environmental Pollution Impairs Human Intelligence and Mental Health
book by Barabara Demeneix
extracts
ABOUT D1 (liver, kidney, pituitary, thyroid)
activate T4 to T3
recirculate iodine from rT3 in the liver (and from other iodothyronines)
stimulated by T4 in most tissues
liver D1 activity decreased by fasting, and increased by carbohydrate meals
ABOUT D2 (D2 activates T4 into T3):
D2 is inhibited by excess T4 (except in Tanicytes) or by rT3
Transcription of DIO2 gene is inhibited by T3
D2 is rapidly degraded by ubiquitination
DIO2 is highly express in the brain, especially in glial cells (astrocytes) and tanicytes (hypothalamus)
Neurons need an efflux of T3 from the glial cells via TH transporters (MCT8, MCT10 and OATP1C1)
D2 is activated by transcription factors nuclear factor kappa and Fox03
D2 in glial cells, brown fat and thyroid cells is stimulated by cAMP
ABOUT D3 (D3 deactivates T4 to rT3 and T3 to T2)
stimulated by T4 in most tissues
high levels of rT3 are found in brain (inhibiting D2 production and braking excess T3 production)
His role is to limit excess exposure to T3
SELENIUM AND MERCURY See P38
(only 45 pages available out of 280)
book by Barabara Demeneix
extracts
ABOUT D1 (liver, kidney, pituitary, thyroid)
activate T4 to T3
recirculate iodine from rT3 in the liver (and from other iodothyronines)
stimulated by T4 in most tissues
liver D1 activity decreased by fasting, and increased by carbohydrate meals
ABOUT D2 (D2 activates T4 into T3):
D2 is inhibited by excess T4 (except in Tanicytes) or by rT3
Transcription of DIO2 gene is inhibited by T3
D2 is rapidly degraded by ubiquitination
DIO2 is highly express in the brain, especially in glial cells (astrocytes) and tanicytes (hypothalamus)
Neurons need an efflux of T3 from the glial cells via TH transporters (MCT8, MCT10 and OATP1C1)
D2 is activated by transcription factors nuclear factor kappa and Fox03
D2 in glial cells, brown fat and thyroid cells is stimulated by cAMP
ABOUT D3 (D3 deactivates T4 to rT3 and T3 to T2)
stimulated by T4 in most tissues
high levels of rT3 are found in brain (inhibiting D2 production and braking excess T3 production)
His role is to limit excess exposure to T3
SELENIUM AND MERCURY See P38
(only 45 pages available out of 280)
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