I know someone who's ordered some dermorphin to try from a Chinese supplier on
www.alibaba.com, after reading about my experiment with dermorphin on the
kambo thread. I will report his results, positive or negative, as soon as I hear them.
Dermorphin is not something I would suggest ME/CFS patients to try though, outside of a clinical trial, because doses are measured in micrograms, and there may be the potential to kill yourself with an opioid overdose if you get the dose wrong (ME/CFS brain fog would make such dosing mistakes easy).
Dermorphin is 30 to 40 times stronger than morphine; you only need 200 milligrams of morphine to induce a fatal overdose, so presumably something like 200 / 40 = 5 mg of dermorphin could kill you.
But I did experience some noticeable improvements in brain fog and sensory hypersensitivity which lasted for 3 days after a single 100 microgram intranasal dose of dermorphin. This is intriguing, as dermorphin has a very short half-life of only 1.3 minutes, so 10 minutes or so after taking it, this substance will have left your bloodstream. Yet I had very noticeable effects that lasted for 3 days.
I am not sure if it is possible, but one thought is that if dermorphin is overstimulating the opioid receptors during this 10 minutes, maybe afterwards the receptors down-regulate (since there is rapid tolerance build-up with opioids), and maybe it's actually the down-regulation that leads to the therapeutic effect. Then after a few days, the down-regulation wears off, and the therapeutic effect ends.
So potentially if you suffer from the chronic pain symptom of ME/CFS, perhaps dermorphin might make this pain worse, if it is down-regulating opioid receptors for a few days (since it's activation of the opioid receptors which reduces pain).
Having said that,
this paper found that dermorphin was better than morphine for controlling post-operative pain in patients, and the analgesic effects of dermorphin were longer-lasting than morphine. Though this long-lasting effect of pain-relieving effect of dermorphin does not make sense to me, given its very short half-life.