I am happy for everybody, who gets better, recovers or has gone into remission!
The problem with all your examples is, that they haven't been tested in a randomised controlled and blinded trial against a placebo treatment. While anecdotal evidence is not worthless (like the observation of Fluge and Mella that some people got better during chemotherapy), it is the weakest evidence, you can get in science. We cannot be sure, if people really got better, because of their treatment, or because of the placebo effect.
Many of these things have indeed been tested in controlled trials, perhaps not specifically for ME, but for say specific symptoms like neurological problems (B12, folate), intestinal permeability (zinc-carnosine and specific strains of probiotics), or antifungals for fungal or mycotoxin infections in ME/CFS patients.
Perhaps you cannot be sure, but I can be, especially as I knew the persons involved prior to and after recovery/remission. And although I mentioned some who I haven't met in person, I've been in contact with them and have known them since at least 2006 (over on ProHealth), so I knew them at their very worst, knew the many things they tried, the things that made them worse and better. To suggest their improvement was based on the placebo effect is insulting, although I'm sure you didn't mean it that way.
Which includes everything from wishful thinking to the regression to the mean to spontaneous remission. Which could occur, especially in mild cases. In a lot of patients ME symptoms fluctuate a lot. So was it really the vitamins or the mold or not? We simply don't know.
You don't perhaps, but they do. Especially those who have ME/CFS-related mold/mycotoxin issues.
What is the natural route? We have just hundreds of anecdotal stories, which haven't been tested in a RCT trial.
People get ME/CFS from a variety of causes, so naturally (pun intended) there will be dozens iof 'routes' involved in their recoveries, as I noted in my original post. No one took one remedy and recovered, just like there will be no one drug for 'the cause' because there isn't one cause.
And you know as well as anyone, that there's a lot more money in drug development than there is in securing funds for studies using treatments that cannot be patented. Those studies went out the window for the most part in the mid-1980's just as the insurance companies and HMOs were taking over the health care system.
I'm not here to argue that anyone is right or wrong. Some will find benefits from drugs, others will not. Some will improve on a combination of allopathic and naturopathic treatments, while others may improve or recover by avoiding drugs completely. Everyone's different.
I just don't think it's fair to dismiss others recoveries/remissions by suggesting that they aren't as real or legitimate because they're "just" anecdotal, or worse, due to "wishful thinking".
Anyway, best of luck with your approach. It will be interesting to see how the final RTX studies come out.