freshveggies
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Hi, Does anyone else have the CBS defect and on a low sulfur diet. I get confusing information on the interest about what I can and cannot eat.
Thanks
Thanks
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Hi, Does anyone else have the CBS defect and on a low sulfur diet. I get confusing information on the interest about what I can and cannot eat.
Thanks
What is CBS defect?
I have 2 CBS +/+ and I eat high sulfur (eggs every day, broccoli, garlic). test your homocysteine. Epigenetics trump genes. I do not eat high protein however. I am good with 80g protein (serum ammonia test to determine) but I seldom actually get that much.Hi, Does anyone else have the CBS defect and on a low sulfur diet. I get confusing information on the interest about what I can and cannot eat.
Thanks
I don't think anyone really argues against epigenetics as an important player in all of this but the combo is telling. I asked my doc about this issue long ago and she said she had yet to find anyone with a fairly clean methylation panel having unexplained disease (leading one to believe that epigenetics or outside influences is the sole contributing factor). I'd caution you to avoid getting into the all or nothing category that so many others seem to do. For many researchers in the field of epigenetics, they are both equally important issues. DNA is no longer considered your destiny and this is where epigenetics factors in hugely for sure.
i'm not sure about what all of your defects are but the serum ammonia also depends on the BHMT, MTHFR A1298c and the NOS so it will spike at different times and is therefore hard to test for in just a random blood or urine test. My doc tested both fairly consistently for a month since I have a full defect there too and many times my levels were fine soon after eating alotta meat only to find they spiked up several days to a week afterward. I think everyone will be different on this depending on their defects and toxic load but then, I'm not stating anything new here since Yasko has said that all along. The tricky thing is that people get fixated on some of the tenets Yasko lays out and nothing is that all or nothing. She emphasizes that repeatedly. She also talks about how the high sulfur cruciferous vegs increase detox through the NAT 1 & 2 detoxification pathway so this can be helpful as well and doesn't suggest getting rid of anything like that entirely, just watching it closely with the CBS and SUOX combo. Its really just considered a bigger problem in those who have the SUOX, which I don't have, thank goodness!
I also believe that other nutritional supports can make a huge difference on this but I choose not to eat high protein more for my nervous system dominance then the CBS factor, though it might be nice to study for correlations between those who are sympathetic dominants and have the CBS defects, especially the full CBS 699T. But thats another subject.
http://www.ncbi.nlm.nih.gov/pubmed/1331380It is suggested that the decrease in IBAT capacity in the rats fed the high protein diet was due, at least in part, to a sustained reduction of sympathetic activity
High protein diets are acidic and people who have sympathetic dominant nervous systems are already way too acidic. This just triggers more fight or flight and nor epi release.
I'm no expert at the nervous system stuff but thats what my doc explained to me, only she explained the chemical reaction which I've since let go. Some of us need lean protein and lots of veggies and complex carbs and others need lots of fatty, grass fed beef, pork, etc with some root veggies. It just depends on your nervous system. You need to read Gestalt's post about nervous systems since he did a great write-up after seeing his nutrigenomics doc.
http://www.gestaltreality.com/2012/07/11/metabolic-diet-supplements-an-exploration/
Meat is full of natural glutamate and aspartate. These amino acids are excitatory and stimulate the sympathetic nervous system
We know that cavemen sure weren't gorging on meat everyday, it was an added bonus
Then other tribes like Eskimos survived on 80% fat and virtually no fruits or vegetables. They were the parasympathetic people and when you understand the nervous systems, that makes alotta sense why they'd need all that meat and fat