I started the hydroxob12 injections - first twice a week starting about 4 weeks ago. My skin started to break out badly (I'm 36 and haven't had a breakout for about 15 years or more) - it took me a while to make the connection that it was worsening with the injections because at the same time, I started using a vitamin C serum. But thinking it was the vit C, I stopped that immediately but my skin only got worse.
My doctor stopped the injections because of a really bad overall crash I've been having and my last injection was about a week to 10 days ago...however, new spots continue to form. I feel like a teenager again. I read that it was a detox but wondering how long it took to clear up for those who have experienced it.
Thanks!
Hi,
There is a school of thought that says any rashes, skin eruptions, etc, are a sign that the B12 is clearing the build-up of homocysteine. I'm told that, typically, women in particular get a rash on their chest. I'm also told that this is transient, and that ultimately you end up with beautiful clear skin.
However, crashing is potentially whole different issue.
I started HB12 injections in Jan/Feb. After two, one a day, I had my standard toxic intolerance response, with a significantly swollen face (esp eyes, nose, mouth), nausea, headache, weakness and generally feeling terrible.
I stopped the HB12 and switched to MethylatedB12 instead. This doesn't seem to cause the same toxic intolerance response.
I started using MB12 patches in Nov/Dec. They gave me considerably more energy than I'd had for years. They also, after about a month, produced the most enormous blind spot on my chin (I'm 55). It still hasn't resolved. I also have a few other uncharacteristic sundry skin eruptions here and there.
I'm willing to believe that transient rashes are due to homocysteine clearance, but I'm also concerned that instead of old toxins coming out, the cause of such skin reactions may be new toxins going in.
It's worth noting that HB12 has to be converted by enzymes into either MB12 or AdenosylB12. MB12 and AdB12 also inter-convert. Whilst hydroxoB12 is the form found naturally in food, and your system may have been able to handle a small dietary amount, you might either have been overwhelmed by the quantity coming in as your injected dose, and /or have been reacting to some other component in the B12 solution. Many of us are deficient in conversion and netralising enzymes and need either or both MB12 and AdB12, in a form we can tolerate and make use of, together with the right form of folate for your system.
My concern about injectable B12 is that I don't know if it's even possible to produce ampoules/ vials of B12 solution without the contents including any preservatives or other potential allergens/ irritants etc that chemically sensitive systems can't neutralise efficiently.
I've also found out that if the contents of MB12 ampoules/ vials are exposed to even small amounts of light, the MB12 very rapidly degrades into HB12. I don't have any specific information re exact times or amounts of light yet.
If you can't tolerate HB12 injections due to a lack of conversion ability, and you try MB12 injections instead, be very careful to immediately wrap your ampoules and any pre-filled syringes (I get 5 syringes out of one 5ml ampoule, each to be used on a different day) in foil to protect them from the light, or you'll just end up injecting HB12 anyway. Since MB12 is about ten times more expensive (at least in the UK), that would just be a huge waste of money as well as time.
Other posters have mentioned folate. It seems that the more B12 you take, the more folate gets used up, so you need to be taking around 800mcg for every mg of B12, or at least, that's what I've gleaned so far from these discussions.
Currently, I seem unable to tolerate Methylfolate, and also any methyl donors. I suspect I have several methyl cycle blocks from SNPs creating a failure to make the right enzymes at the right points in the cycle. I'm better on folinic acid, which uses a different pathway. Methylfolate makes me highly anxious within an hour or so of taking it. Curiously, the transdermal patches that I did so sell on in Dec/ Jan, only had straight folic acid in, which I wouldn't have expected I'd have been able to convert at all.
One last thing about B12 injections - subcutaneous injections tend to work better whilst we're replenishing a B12 deficiency, because it releases more slowly into the bloodstream and subsequently our serum levels stay elevated for longer.
Intramuscular injections cause a rapid elevation of serum B12 levels, which then fall just as fast when the body works harder to excrete these unexpected and suddenly high levels. (I haven't explained that very well, but it made sense when I first read about this being the main difference between SC and IM injections!)
Do you know which form of B12 your doc is giving you, and whether it's being administered subcutaneously or intramuscularly?
-Hope at least some of that helps you
