Great video!
IMO, they have the primary causes of ME/CFS and the right basic pathology.
Multiple infections, (and I think other things), that cause sensitized microglia and neuro-inflammation. Which they think is the primary cause of symptoms, as does Jarred Younger.
I'm really happy to see them integrating dysbiosis, and leaky gut, more and more into their hypothesis, as a cause of ME/CFS.
And how inflammation from dysbiosis can activate the vagus nerve around the gut, travel up the vagus nerve to the brain stem, activate microglia, which activates the sickness response.
Which can cause fatigue, pain, malaise, and many flu-like feelings, and I think Micheal even said it can cause anxiety. I really feel that they have the best hypothesis I've heard to date.
Once the microglia become sensitized, it doesn't take very much to fully reactivate them. This is what causes PEM, I think. I almost always feel sick to some extent, with fatigue, malaise, pain, etc.
I think this comes from how activated the microglia in my brain are. The less they are activated, the milder my symptoms. The more they are activated, the worse my symptoms are.