@ebethc - 23andMe still tests for rs8084, but it's now labeled as i5015193 and i5028329 on the V4 chip. If you can post your result for those I might be able to narrow down your second DRA type a bit further.
i5015193 = AC
i5028329 = AC
Thanks!
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@ebethc - 23andMe still tests for rs8084, but it's now labeled as i5015193 and i5028329 on the V4 chip. If you can post your result for those I might be able to narrow down your second DRA type a bit further.
In that case you have an A allele at rs8084 which goes with the DRA*010203 type, leaving rs8084 C for your other type. rs8084 C excludes *010102, so your two types should be DRA*010203 and DRA*010101.i5015193 = AC
i5028329 = AC
In that case you have an A allele at rs8084 which goes with the DRA*010203 type, leaving rs8084 C for your other type. rs8084 C excludes *010102, so your two types should be DRA*010203 and DRA*010101.
Dunno, there might be some research associating various HLA-DRA types with predispositions to various illnesses But HLA-DRA is generally pretty unexciting, as far as HLA genes go.So, what does that mean?
Dunno, there might be some research associating various HLA-DRA types with predispositions to various illnesses But HLA-DRA is generally pretty unexciting, as far as HLA genes go.
No, 23andMe can't handle most HLA testing. The interesting SNPs which determine HLA types on other genes usually have 3-4 alleles, and 23andMe only includes SNPs with 2 alleles.thanks, @Valentijn .. Where can I learn more about HLA DR? I'd love to know how I test for all of the HLA DR's; is there a way to get that out of 23andme?
His claims about HLA types are unsubstantiated by proper research. He claims correlations based on comparing the HLA types of his mold patients with international rates of HLA types, but that doesn't work because HLA is closely associated with ethnic origins, and most of his patients have very similar ethnic origins. In fact, if you do the math and compare his "bad" HLA types with HLA prevalence rates in North Americans, approximately 85% of all North Americans are highly susceptible to various substances.I'm listening to podcast #126 - Interview w RIchie Shoemaker on Mold toxicity... fascinating! Good discussion..
https://www.bulletproofexec.com/126-dr-ritchie-shoemaker-on-surviving-mold-podcast/
https://www.bulletproofexec.com/wp-content/uploads/2014/06/Transcript-126-Dr.-Ritchie-Shoemaker.pdf
The first SNP is rs7129, not rs719259. If you are GG for rs7129, your HLA DRA type is homozygous for *010101. If you have AA for rs7129, your HLA DRA type is homozygous for *010201. If rs7129 is AG, you're heterozygous for *010201 and *010101.rs719259 = CC
rs8084 = CC
rs11544315 = CC
rs3135391 = GG
The first one needs to show rs7129, and the 2nd one needs to show rs8084. Until then, there's not enough data, except to exclude *010203.rs719259 = CC
rs808421 = CT
rs3135391 = GG
I took a look at the position of the SNP on the chromosome and it definitely seems to be missing from the newer V4 chip results.Did they stop testing that one?
I haven't seen any solid indication that HLA DRA type is associated with mold reactions. But there is a somewhat common missense mutation at rs16910526 on the CLEC7A gene, where AC or CC genotypes result in increased susceptibility to candida, aspergillus, and pneumocystis jirovecii infections.I'm really worried about the impact of mold on my daughter.
So you're homozygous for DLA DRA *010101. Your daughter would at least be heterozygous for it as well.Here is the revised list:
rs7192 = GG
rs8084 = CC
rs11544315 = CC
rs3135391 = GG
So you're homozygous for DLA DRA *010101. Your daughter would at least be heterozygous for it as well.
... not much According to wikipedia, I think they're saying that HLA-DRA type doesn't have any effect, and all types create the same protein:So...what does that mean?
That would make sense, since the SNPs used to determine HLA-DRA type aren't missense mutations.
It means you're homozygous for DRA*010202. DRA types don't seem to be significant.My genes are showing mutations. what does this mean?? Is it significant? Thanks
rs7192 = TT ++
rs8084 = AA ++
rs11544315 = CC --
rs3135391 = GG --
It means you're homozygous for DRA*010202. DRA types don't seem to be significant.
The SNPs for this haplotype are listed above. I'm not sure what you mean by "others": other people? Other haplotypes?You are absolutely brilliant. Where can one determine the SNP constituents of a haplotype in order to perform similar calculations with others?
The SNPs for this haplotype are listed above. I'm not sure what you mean by "others": other people? Other haplotypes?
I don't remember where the SNPs were listed. There are databases of HLA haplotypes, but they're pretty useless with 23andMe data since they can't test the important SNPs.The SNP constituents for other haplotypes for other genes. For example, where can you determine that those four SNPs comprise those HLA-DRA haplotypes? Is there a database where haplotypes are defined by their SNP constituents?
Dunno, there might be some research associating various HLA-DRA types with predispositions to various illnesses But HLA-DRA is generally pretty unexciting, as far as HLA genes go.