Hi
@Jimbo39 seems we are in the same boat.
I saw a cardiologist recently and I understand from my doctor (the cardiologist did not tell me directly) that my pressure was either 180/80 or 160/80. I cannot remember which.
I felt really calm that day, and was lying down when he measured my blood pressure.
Anyway the cardiologist prescribed candesartan which I tried for 5 days at 4mg/day.
I found that the drug made me much calmer, which was nice, but after a few days it also seemed to make doing anything impossible. My brain could not entertain thought, I could not stand up long enough to cook. So I stopped the drug (last dose wednesday) and am better in some ways and worse in others but not fully recovered yet.
I do not know, but fear, that the increased pulse pressure is my body's adaptation to the mess that is my cardiovascular system. My way of getting O2 to my tissues in the face of some host of autonomic failures assoiciated with my CFS/ME, seems to be altering the functioning of my heart instead using the usual combination of variations to veins and arteries and heart and I do not know what else.
The Candesartan made my POTS much much worse. It was like being in PEM. Over 100bpm just standing, 70s and above just sitting at the desk, which I could not do for more than 45 minutes a couple of times a day. (I am usually in the high 50s or low 60s sitting at the desk).
I ended up spending my days either lying down, or sitting in a reclining chair with my legs up (and could really feel that difference of maybe 15 or 20 degrees).
I rather hope that I can convince the cardiologist to look more deeply into it and that these symptoms prove in some sense diagnostic or at least indicative of something or other.
Someone who had a better handle on OI might be better placed to comment.
fingers crossed for both of us.