ljimbo423
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have never come across a "Th1 exhaustion" hypothesis. Did you read about this somewhere?
I read about immune exhaustion in cfs here-
The researchers reported that patients were flush with cytokines and chemokines until around the three-year mark -- suggesting an over-activated immune response in that phase of the illness; thereafter the immune system showed evidence of "exhaustion," and levels of immune molecules dropped
Although they don't say th1 immune exhaustion, I made some connections myself that made sense, at least to me. Because high levels of viruses or titers are found in many with cfs and so many, but not all, catch more than the average amounts of colds and flu's, etc. I am assuming it is the th1 arm that becomes exhausted, at least in some.