roxie60
Senior Member
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- Central Illinois, USA
thank you
freshveggies, how did you get your NOS value? Did you take Tasko's test to get that one?
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thank you
Thanks guys for pursuing this, this result (AA full defect) now makes more sense given my health experience. I was stunned to have VDR Taq AA and VDR BSM CC be both no variant with original run and I have such difficult time getting my vit D levels just to the low end of the range (taking 5000-10000 / day). Now VDR Taq would be red even though still -/- due to A being the risk allele (provided I am understanding this stuff at all).
(no data from 23andMe on VDR Fok - I really wish they would add this one and a few of the other methylation SNPs that are missing but they are making progress since it seems version 3 had added some SNPs)
My question to some one is I am still looking to understand how to look at the 23andMe SNPs and determine what is the risk allele for the SNP. For example of the following SNPs how do I know which is the risk allele, how I determine the '+' '-' status? Thx I have completed the Detox SNPs manually but I am basing the result spreadsheet rather than my personal understanding. I would like to understand so I can apply to other SNPs I'm looking at
I made the changes. A is now the risk allele.
freshveggies - you come out as AA and -/- because the risk allele was G. Now if you upload your results, you will see the opposite.
Which does not explain Fresh Veggie's Yasko vs. 23andMe results. Maybe Sushi can chime in? I believe there are known to be discrepancies amongst the tests from various labs.
OK, this is interesting--just in that now 2 labs seem to be disagreeing with Yasko. I haven't read this whole thread but a couple of patients had both Yasko and RedLabs VDR test and the results from the two labs were different. So maybe Yasko is off the mark? Or am I reading this wrong?
Sushi
Also, on my oats test from Genova, my alpha-ketogluterate was off the charts. Any ideas, ladies or gents?
Any thoughts?
I wonder where the rational behind a CBS upreg leading to higher alpha-ketoglutarate comes from? CBS upreg according to the yasko diagram increases alpha-ketobutyric. Maybe heartfixer got the 2 confused?
If you have the CBS upreg, I found yucca to be very beneficial to myself in terms of soaking up excess ammonia which was causing me extreme Excitotoxicity.
Heartfixer does not explain the mechanisms behind this statement: "Genomic defects, viral illness, and heavy metals will compromise this balance, leading to excess glutamate"
If there broad issues in the methylation pathway (CBS, MTHFR,DHPR,NOS,OTC) these will all lead to excess ammonia levels which is a potent excitotoxin. This causes microglial activation which in turn causes a drastic increase in glutamate levels and therefore probably akg levels.
Source: "When activated by proinflammatory stimuli, microglia release substantial levels of glutamate, and mounting evidence suggests this contributes to neuronal damage during neuroinflammation."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949347/
So therefore, to get rid of ammonia, fix methylation pathways, take yucca, eliminate dietary sources of free-form glutamate (most refined foods, especially wheat or anything with a "flavor" or "spices" additive; click on this for extended list) and that should help control the "excess glutamate" problems.
Thanks Gestalt: Wow, a whole new paradigm sift? So, I am doing targeted amino acid therapy right now. As I have really bad brain fog, does this mean the L-glutamine I am taking is neuro toxic? That is what most of the md's are asking patients to take for "gut repair".
Any ideas how I can get a crash course on this (if my brain will let me). I did the Yasko profile. Was it a waste of time?
I am one that can't handle glutamine. I get overstimulated with each 3.5 g scoop. It overstimulates me to the point that I can't concentrate on anything. I gave the supplement away.
I am not convinced that it can't have a negative effect on glutamate levels for some.