soulfeast
Senior Member
- Messages
- 420
- Location
- Virginia, US
I'll use this post to thank everyone who has responded. I ordered 1mg jarrow mb12 so I can start slow and have a more equal ratio with preference toward the metafolin. We will see what happens. My symptoms are better now.. legs hurt though. I took 5 mg jarrow mb12 and 400mcg metafoliln.. so back to where I was with metafolin before I started.
I will go slow at least starting with 1 mg mb12... also interesting info, rydra.. thank you. i have not had homocysteine checked in a long time. would be interesting to see where that is and I do take 200mg of p5p a day but I skip days and had probably skipped a week at some point during this quick ramp up..
I will go slow at least starting with 1 mg mb12... also interesting info, rydra.. thank you. i have not had homocysteine checked in a long time. would be interesting to see where that is and I do take 200mg of p5p a day but I skip days and had probably skipped a week at some point during this quick ramp up..
I think if you are frightened you should stop using anything that frightens you. Your body may be telling you that what you are doing is dangerous FOR YOU. For instance if you have a low potassium situation and you persist it can kill you very fast. That is why I think you should take things slow and moderate. Do not underestimate the value of a simple CBC with chem (which is cheap and can be gotton via LABCORP) so you can test your electrolytes frequently even if a doctor wont authorize it. I wanted to spend my money on fancy tests but Life Extension ran their yearly blood test sale and went on and on about the value of a simple overall blood screening so I decided to run it even though I'd had those run before and never found anything. Things change! Mine detected hyperthyroid. Yours could detect low potassium.
Well, anyway, IMHO dont let anyone else tell you to do something that makes you feel bad. No one knows your body like you.
That said, I wouldnt take glutathione personally. I have taken milk thistle (in a small dose 2 out of a 6/day of a powdered milk thistle from eclectic institute - not concentrated or anything) to no ill effect. The only thing it did for me is get rid of the inflammatoy cytokines caused by insufficient sleep (and I felt it in my knees - it takes away joint pain caused by lack of sleep). I felt it provided a bit of protection for my liver. However I have since read that milk thistle, even in dietary doses (whatever that means because no one I know sprinkles it on their food) increases absorption of your stomach contents significantly - so do NOT take it with medications - it is like taking grapefruit juice. Well, anyway, that form of cysteine did not destroy MY methylation - my homocysteine on it was 6.1 - PERFECT.
I believe that when you start taking methylation supplements you will almost certainly RAISE your homocysteine (neurotoxin) temporarily (which could cause ms-symptoms or even stroke or heart attack). When I started taking it I looked at the whole methyl cycle (the biochemical pathway) and took EVERYTHING on it at once - in particular an extra 50mg P5P. P5P is the only nutrient in the cycle that can lower your homocysteine immediately. I know that other supplements (TMG, mfolate, mB12) are known to lower homocysteine...but they simply CYCLE it back into homocysteine! If YOU have high homocysteine to start, *I* think it would be safest to drain it away with P5P and THEN start getting the methyl cycle working. Looking at the biochemical pathway of the methyl cycle *I* would *never* start with SAMe as it is only 1 step away from homocysteine, which may already be high. Depending on your genes and your prior nutritional state, it may be VERY high. So maybe that is what you feel. I would drain it away before I started raising my doses of the other recycle supplements. That is just my opinion.
Remember I took B100 all my life - that is 100mg B6 per day - and it kept my homocysteine from getting higher than 12 (which is bad, b.ut many people have theirs as high as 50 or 70). I believe that is why I never had startup symptoms when taking the active protocol. I also believe that the reason I DID have startup sysmptoms when picking and choosing and starting up the second time after I quit most everything due to nausea from too many pills that my homocysteine probably went above 12 and was the cause of the startup symptoms. I did not test, I just went slow, starting with only Thorne Basic B 2x/day, nothing else (but when I experienced symptoms of startup I started the P5P and also potassium). I do not know how long P5P takes to lower homocysteine - it would depend on how high someone's is, how much P5P they take, probably also what else they take with it (some things UP/DOWN reg different genes), and also on kidney functionality because it gets peed out and if you have poor kidney filtration you will indeed have high homocysteine. If you have poor kidney filtration you should not be experimenting w/o a doctor helping you.