PeterPositive
Senior Member
- Messages
- 1,426
I am MTHFR C677T +/+. Recently I started oral Metafolin (800mcg) and haven't seen any improvements or side effects. Then I switched to sublingual methylfolate , same dosage, which has caused extra anxiety but more importantly severe worsening of the GI issues.
I have a hard time thinking that this is some kind of folate intolerance, otherwise I would have seen the same symptoms when taking it orally (I have tried both Quatrefolic and Metafolin, same thing).
At the moment I can barely handle half sublingual tablet (400mcg) which is accompanied by Metyhl-B12 and Adenosyl-B12 (1000mcg in total). I have no problem with both forms of B12 even at higher dosages.
I am suspecting this is an example Paradoxical Folate Deficiency?
If I remember correctly I read Freddd or someone else saying that when folate and B12 re-start the healing process new cells are built more quickly, but if the amount of folate in the system isn't enough to maintain them they will die very rapidly...
Am I making any sense?
My biggest problem has always been functional digestive issues (not IBD, but very strange form of IBS), with sublingual methylfolate the issue is exacerbated pretty quickly, typically 2-3 days. I have done a couple of tests: stopping the supplement I get relief in 24-48 hours. Then I reintroduce it and things worsen in another 48-72 hours.
Besides trying to push through this, is there any advice that I can try?
If this is a paradoxical deficiency and I need say 10x the folate (and B12) to sustain healing how am I going to get there without dying? Seriously 400mcg are already killing me.
I will try to stay on this dose for some time and see if it's just a temp issue, but if you guys have had similar experience or have suggestions, please let me know.
Thanks
Peter
I have a hard time thinking that this is some kind of folate intolerance, otherwise I would have seen the same symptoms when taking it orally (I have tried both Quatrefolic and Metafolin, same thing).
At the moment I can barely handle half sublingual tablet (400mcg) which is accompanied by Metyhl-B12 and Adenosyl-B12 (1000mcg in total). I have no problem with both forms of B12 even at higher dosages.
I am suspecting this is an example Paradoxical Folate Deficiency?
If I remember correctly I read Freddd or someone else saying that when folate and B12 re-start the healing process new cells are built more quickly, but if the amount of folate in the system isn't enough to maintain them they will die very rapidly...
Am I making any sense?
My biggest problem has always been functional digestive issues (not IBD, but very strange form of IBS), with sublingual methylfolate the issue is exacerbated pretty quickly, typically 2-3 days. I have done a couple of tests: stopping the supplement I get relief in 24-48 hours. Then I reintroduce it and things worsen in another 48-72 hours.
Besides trying to push through this, is there any advice that I can try?
If this is a paradoxical deficiency and I need say 10x the folate (and B12) to sustain healing how am I going to get there without dying? Seriously 400mcg are already killing me.
I will try to stay on this dose for some time and see if it's just a temp issue, but if you guys have had similar experience or have suggestions, please let me know.
Thanks
Peter
Last edited: