I am at 8 weeks now of Rinvoq, and most of my symptoms seem to have returned. It doesn't look great for Rinvoq in my case.
Exceptions are a mild reduction in stamina (I work/walk/go longer before becoming fatigued) and in brain fog (I can keep enough focus now to read and light study once again). Also, some of my arthritis like symptoms have abated some - including a reduction in those pains, and a near resolution of the long standing psoriasis on my knees.
The fatigue and daytime sleepiness symptoms persist as they always have, as well as many of the aches/pains.
My summary is this is not at all the silver bullet for CFS I had hoped it might be.
After going through a few 'silver bullet hopefuls over the years, I was prepared for that outcome, and my expectations were low. So, for now, I will accept the gains presented and keep pressing on with Rinvoq. I will update here with anything meaningful.
As this was my 4th or 5th attempt at arthritic/immune system treatments (prednisone, methotrexate, sulphasalazine, anti-tnf's, and now Rinvoq), all of which helped a little but never a lot, I think I am becoming confident that the root of my issues is not due to an ongoing immunological issue.
Disappointingly, if this is not an immunological issue, I am left with very little that explains just what is driving all of this.
We persevere.