Interesting!
http://www.sciencedaily.com/releases/2015/06/150616093646.htm
Yes they talk about extreme exercise but what if in ME the bar is just so much lower for this effect to take place (ie endotoxin leak through gut lining into bloodsteam following less than extreme strain) AND/OR the subsequent calming down of the immune system does not take place as it should ... and voila PEM?
http://www.sciencedaily.com/releases/2015/06/150616093646.htm
Blood samples taken before and after the events, compared with a control group, proved that exercise over a prolonged period of time causes the gut wall to change, allowing the naturally present bacteria, known as endotoxins, in the gut to leak into the bloodstream. This then triggers a systemic inflammatory response from the body's immune cells, similar to a serious infection episode.
Significantly the study found that individuals who are fit, healthy and follow a steady training program to build up to extreme endurance events, develop immune mechanisms to counteract this, without any side effects.
However individuals who take part in extreme endurance events, especially in the heat and with little training, put their bodies under enormous strain above the body's protective capacity. With elevated levels of endotoxins in the blood, the immune system's response can be far greater than the body's protective counter-action...
...
The research team found that people who were fitter and trained over a longer period of time leading into the ultra-marathon event had higher levels of Interleukin 10 -- an anti-inflammatory agent, which allowed them to dampen down the negative health impacting immune response.
"The body has the ability to adapt and put a brake on negative immune responses triggered by extreme endurance events. But if you haven't done the training and you're unfit -- these are the people who can get into trouble," Dr Costa said.
Yes they talk about extreme exercise but what if in ME the bar is just so much lower for this effect to take place (ie endotoxin leak through gut lining into bloodsteam following less than extreme strain) AND/OR the subsequent calming down of the immune system does not take place as it should ... and voila PEM?
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