I accidently discovered that I had a partial empty sella when my Testosterone was dangerously low and would not come back up even with shots. My Doctor (regular GP who knows nothing of ME CFS) said it was nothing. Later I found a real ME CFS Doctor who prescribed a biodentical form or testosterone cream that works great. They did an MRI because they were looking for a pituitary tumor. (none found) I believe that I have spinal fluid in my brain that flattens my pituitarty gland because of some type of post viral illness that is involved in this illness. I would not expect to find any good research on this. I did at a lot back in 2010. Nothing. Partial Empty Sella is typically found in women. Zensational, do you have chronic pain? I do and I think it is related to how my brain regulates pain.
I too accidentally discovered that I had partially empty sella when I was having migraines and had an MRI to rule out a tumor. Pituitary tumors can be so small that they are not detectable on MRI. None found though. So when I first became ill with CFS/ME, then referred to as "yuppie flu", I was having motor problems so off to the neurologist. He found an enlarged pituitary. Didn't have a clue why.
My conclusion is that the infection EBV, caused the enlargement of the pituitary gland and now it is an empty sella. Yes I do have muscle pain. My best thinking is that the pituitary regulates growth hormone, which I have very little of. Growth hormone is what is needed to get stage 4 sleep. I don't get nearly enough of that either. Sooo, I think that's why I expereince the pain.
I take valerian, passiflora and a small dose of melatonin, 1mg. No caffeine, no excitement late in evening. Breathing and muscle relaxation exercises.
I am unable to tolerate any of the sleep drugs.
Hope this helps. Let me know how you are doing.