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Dr. Amy Proal interviews Dr. Liisa Selin about T cell exhaustion and viral activity in ME/CFS

Learner1

Senior Member
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Pacific Northwest

pattismith

Senior Member
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  • CD8 and NK cells are low in number in ME/CFS
  • .
I do have low CD8 and my CD4/CD8 ratio is about 5.


This ratio is higher in females and is mostly under genetic control. But I just read this old paper, and it makes me wonder if Glutathione deficit might be a major factor in ME/CFS.
I feel also better with glutathione supplementation...

Differential effects of glutathione depletion on T cell subsets - PubMed (nih.gov)

. Depletion of intracellular GSH by buthionine sulfoximine (BSO), a specific inhibitor of GSH biosynthesis, decreases the proportion of CD8+ cells (i.e., increases the CD4+/CD8+ ratio), and inhibits particularly the generation of large blast-like CD8+ cells and cytotoxic T lymphocyte (CTL) activity.
 
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Not sure about 5 antioxidants but to save people time, here’s a summary of the patented ingredients. Seems to be any combination of the mentioned aminos acids + vitamins + chelating agents + antioxidants with a vape administration. A fifth element is (TRPA1 antagonist) is included for delivery via the lungs I believe. Lots of usual suspects in the proposed ingredient list.

“In an embodiment of the invention, a pharmaceutical composition includes at least one plant extract Transient Receptor Potential Cation Channel, Subfamily A, member 1 (TRPA1) antagonist, at least one thiol amino acid containing compound, at least one vitamin, at least one chelating agent, and at least one antioxidant. The plant extract TRPA1 antagonist can be 1,8-cineole, borneol, camphor, 2-methylisoborneol, fenchyl alcohol, cardamonin, or combinations. The thiol amino acid containing compound can be a naturally-occurring compound. The thiol amino acid containing compound can be glutathione, N-acetyl cysteine, carbocysteine, taurine, methionine, or combinations. The vitamin can be a cobalamin, methylcobalamin, hydroxycobalamin, adenosylcobalamin, cyanocobalamin, cholecalciferol, thiamin, dexpanthenol, biotin, nicotinic acid, nicotinamide, nicotinamide riboside, ascorbic acid, a provitamin, or combinations. The chelating agent can be glutathione, N-acetyl cysteine, citric acid, ascorbic acid, ethylenediaminetetraacetic acid (EDTA), or combinations. The antioxidant can be a naturally-occurring compound. The antioxidant can be berberine, catechin, curcumin, epicatechin, epigallocatechin, epigallocatechin-3-gallate, β-carotene, quercetin, kaempferol, luteolin, ellagic acid, resveratrol, silymarin, nicotinamide adenine dinucleotide, thymoquinone, 1,8-cineole, glutathione, N-acetyl cysteine, a cobalamin, methylcobalamin, hydroxycobalamin, adenosylcobalamin, cyanocobalamin, β-caryophyllene, or combinations.”