alex3619
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J Affect Disord. 2011 Dec 12. [Epub ahead of print]
Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression.
Maes M, Ringel K, Kubera M, Berk M, Rybakowski J.
http://www.ncbi.nlm.nih.gov/pubmed/22166399
This study shows that over half of depressive patients (in a smallish sample size) have antibodies that might induce it. This includes anticardiolipin antibodies, which are also often found in ME, see the link below. So it may turn out that much of the depression in ME is attributable to autoantibodies. The authors suggest that a driving force behind depression, including in CFS, is an increasing autoimmune response.
Here is an earlier study:
Autoimmunity in depression: increased antiphospholipid autoantibodies
M. Maes1,2,3,*,
H. Meltzer1,
J. Jacobs4,5,
E. Suy2,
J. Calabrese1,
B. Minner2,
J. Raus4
Article first published online: 23 AUG 2007
DOI: 10.1111/j.1600-0447.1993.tb03349.x
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0447.1993.tb03349.x/abstract
Bye, Alex
Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression.
Maes M, Ringel K, Kubera M, Berk M, Rybakowski J.
http://www.ncbi.nlm.nih.gov/pubmed/22166399
This study shows that over half of depressive patients (in a smallish sample size) have antibodies that might induce it. This includes anticardiolipin antibodies, which are also often found in ME, see the link below. So it may turn out that much of the depression in ME is attributable to autoantibodies. The authors suggest that a driving force behind depression, including in CFS, is an increasing autoimmune response.
Here is an earlier study:
Autoimmunity in depression: increased antiphospholipid autoantibodies
M. Maes1,2,3,*,
H. Meltzer1,
J. Jacobs4,5,
E. Suy2,
J. Calabrese1,
B. Minner2,
J. Raus4
Article first published online: 23 AUG 2007
DOI: 10.1111/j.1600-0447.1993.tb03349.x
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0447.1993.tb03349.x/abstract
Bye, Alex