pattismith
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863389/
Comorbidity of Epilepsy and Depression: Associated Pathophysiology and Management
Epilepsy of the temporal lobe (also known as temporal lobe epilepsy, or TLE) is a useful biological model for understanding the anatomical similarities between depression and epilepsy.
TLE and clinical depression may be linked to an increase in hippocampus interleukin-1beta (IL-1beta) signaling as suggested by Mazarati et al. that increased IL-1B causes dysregulation in the hypothalamo-pituitary-adrenocortical axis (HPA) [21,22].
This dysregulation impaired raphe-hippocampal serotonergic transmission and led to depressive symptoms.
Additionally, the purpose of this study by Mazarati was to determine if pharmacological inhibition of the hippocampus interleukin-1 receptor had antidepressant effects in an animal model of TLE and depression that occurred in Wistar rats following pilocarpine status epilepticus (SE) [21].
Bilateral intrahippocampal infusions of human recombinant Interleukin-1 receptor antagonist (IL-1ra) for two weeks alleviated all depression symptoms in naive rats without changing spontaneous seizure frequency or normal parameters.
These findings link hippocampus IL-1beta in epilepsy-associated depression and support the use of IL-1beta antagonists in TLE treatment [21]........