@Methyl Head @dannybex and others,
I now have evidence that the hyperammonemia may not be caused by 10x up-regulation of CBS (discrediting Yasko). Most probably it's being caused by Mitochondrial defects (genetic or acquired as Mitos are very dynamic) systemic or liver-specific. In liver, mitos play a very special role in ammonia processing. Subtle defects in mtDNAs may act like a case of hyperammonemia.
Careful, one of Yasko's suggestions for fixing CBS (which may have been exaggerated) - Yucca Root contains potent saponins which are known to make leaky-gut worse. And leaky-gut itself may be caused my mito dysfunction. Mitos are known to participate in cross-talks with our gut microbiome and often butyrate is involved. There are papers available for it. So low butyrate and microbiome imbalance can actually be an subtle effect of harbouring dysfunctional mitos and colon/uterus are sensitive to such dysfunction (heart and brain cells are have already divided and matured ?)
And mito-dysfunction will cascade to glutathione issues for sure. Cu/Zn balance can be explained by increased production of Zn-dependent mtSOD2 etc. So yeah, Yasko has created a CBS-cult. But science is about continuous exploration.
What you can do to make sure that it's not a mito dysfuntion
- MitoSwab test
Protocols now I'm taking to better overall health and mito-health is to go through a cycle of mito fission and fusion inducing strategies. A senolytic protocol would be good prerequisite before embarking on that protocol.
And try to take as much as natural foods as opposed to supplements, unless you are at a very bad shape genetically.
Senolytic Protocol
------
Quercetin + Fisetin (strawberries and onions, onions and onions; but supplement here is better)
Infrequently once in 2/3 months
Fission-Fusion Protocol (3 days)
------
Defective mitos are usually fused and avoid mitophagy. The idea is to induce fission or at least encourage it via precision protocols. NAD+/NADH ratio, AMPK, mTOR all influences mitophagy
- 20hs+ or 18:6 IF Fasting (its pro-fusion and but more % of fission happens at early phase overnight)
- Apigenin (celery + parsely)
- Nicotinamide+Ribose (careful as it induces NAD+. so a solid senolytic protocol must proceed this)
- Yogic Intermittent Hypoxia (YIH)
- Weight Lifting
etc.
As mitos are fragmented evolutionarily preserved proteins Drp1 starts tagging dysfunctional mitos (after fragmentation its easier for a cell to identify poor performers) for a sweeping mitophagy
Fusion (2 days)
--
CoQ10 / Ubiquinol
PQQ
Vitamin C
Aerobics (cycling)
In fact most of the anti-oxidants are pro-fusion and protects the mitos directly or indirectly via NRF2-glutahione/SOD1/2
Rest: 1/2 day(s)
Cycle this for couple of rounds and measure VO2-Max, HR variability (as cardic metrics will improve with better mitos) and repeat MitoSwab, if you have money.