We were discussing in another thread the possible (and very plausible) theory that if ME/CFS is autoimmune it could be that autoantibodies are being generated against parts of the brain and the damage or change in function they might cause would result in all the symptoms we experience. Here is a good introductory paper on the topic:
Brain-reactive antibodies and disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401150/
As I mentioned in the other thread, I believe that the major ME/CFS research groups should start spending at least some time/resources to study the autoimmune hypothesis, whether it's the above, or Fluge/Mella's current theory that autoantibodies might be generated that are interfering with vascular function, or other possibilities.
Lipkin/Hornig, Montoya, Younger, Davis/Kogelnik/OMF, none of the big groups have even opened to the idea of spending some of their resources to study autoimmunity in ME/CFS, even as more and more evidence has come out of Norway these last few years. @Sushi mentioned to me that KDM is currently working on his autoimmune hypothesis (see http://phoenixrising.me/archives/16017), although it is very different from the ones mentioned above, but at least he is thinking about it.
Brain-reactive antibodies and disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401150/
As I mentioned in the other thread, I believe that the major ME/CFS research groups should start spending at least some time/resources to study the autoimmune hypothesis, whether it's the above, or Fluge/Mella's current theory that autoantibodies might be generated that are interfering with vascular function, or other possibilities.
Lipkin/Hornig, Montoya, Younger, Davis/Kogelnik/OMF, none of the big groups have even opened to the idea of spending some of their resources to study autoimmunity in ME/CFS, even as more and more evidence has come out of Norway these last few years. @Sushi mentioned to me that KDM is currently working on his autoimmune hypothesis (see http://phoenixrising.me/archives/16017), although it is very different from the ones mentioned above, but at least he is thinking about it.
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