globalpilot
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Excellent research and explanations Hip. Have you tested positive for enterovirus ? So I guess if the daughters can carry the infection non-cytolytic cells can essentially infect new cells then.
I went to my doctor Thursday and showed him Dr Chias findings. He is not on board and does not think this is a causal factor. He pointed to Lyme and mycoplasma as possibilities. And the enterovirus as an outcome of having Lyme (suppressed immune system I guess). How does one respond to this ?
I went to my doctor Thursday and showed him Dr Chias findings. He is not on board and does not think this is a causal factor. He pointed to Lyme and mycoplasma as possibilities. And the enterovirus as an outcome of having Lyme (suppressed immune system I guess). How does one respond to this ?
Chia's research focused on enteroviruses in the gut (both the cytolytic and non-cytolytic subsets) because the gut is a main reservoir of enteroviruses in the body, and because it is relatively easy to take tissue sample from the gut. However, the mental symptoms of CFS are probably underpinned by these same cytolytic and non-cytolytic infection in the brain (but of course nobody living with CFS is going to donate a part of their brain in order to test this...).
It is known that enteroviruses can ascend the vagus nerve that runs from the gut to brain in three days. So this is one route of entry that enteroviruses have into the brain.
Coxsackievirus B seems able to infect the astrocyte cells in the brain (an astrocyte is a type of glial cell), according to this recent paper from China. And a postmortem examination of the brain, performed on a deceased CFS patient of the late Dr John Richardson (who had studied enteroviruses in CFS for 50 years), found lots of enterovirus infection in the outer (exterior) lining of the blood vessels in the brain, and some enterovirus infection in the glial cells.
The difference between a cytolytic and a non-cytolytic enterovirus is simply that the non-cytolytic version has had a tiny part of its genome deleted and removed the part that encodes for the shell of the virus (capsid). Thus the non-cytolytic version is identical, except that it has no shell. The analogy think of for this is that a non-cytolytic enterovirus is like a snail without its shell.
In essence, the non-cytolytic enterovirus is just a naked RNA genome.
I am not sure whether this shell-less non-cytolytic enterovirus can jump into new cells or not (I have not seen any research that confirms or refutes this possibility). However, since there are likely thousands of copies of this naked RNA an infected cell, presumably if that cell divides to create daughter cells (mitosis), the daughters will also carry the infection.
Refs:
Coxsackievirus Infection Induced Cytopathy and Cytokine Secretion in Astrocyte.
J. Richardson. (2001). Viral Isolation from Brain in Myalgic Encephalomyelitis (A Case Report).