- Messages
- 52
For my ME/CFS: Untreated hypothyroidism and hardship/overexertion caused metabolic damage to the CNS. Exertion causes easy fatigue of functions such as movement, cognitive functions, as well as autonomic functions. Pushing past the fatigue releases endorphins, which cause PEM and brain fog.
Naloxone cures the PEM and brain fog by antagonizing endorphins, but not the fatigue or possible damage. The damage caused by hypothyroidism could be due to localized lactic acidosis. Anion gap was high for many years, and would be much higher in the brain, considering it's a metabolically active organ.
Treatment is ramping up thyroid, supplementing thiamine, and increasing cerebral blood flow, all of which reduce lactic acid formation in the CNS and give the brain an oppurtunity to heal.
Naloxone cures the PEM and brain fog by antagonizing endorphins, but not the fatigue or possible damage. The damage caused by hypothyroidism could be due to localized lactic acidosis. Anion gap was high for many years, and would be much higher in the brain, considering it's a metabolically active organ.
Treatment is ramping up thyroid, supplementing thiamine, and increasing cerebral blood flow, all of which reduce lactic acid formation in the CNS and give the brain an oppurtunity to heal.