bacterias in TMJ fluid in RA

[deleder2k]

Juvenile idiopathic arthritis and rheumatoid arthritis: bacterial diversity in temporomandibular joint synovial fluid in comparison with immunological and clinical findings.


http://www.ncbi.nlm.nih.gov/pubmed/26554824

Abstract
Temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA) occurs in up to 80% of affected children. The purpose of this study was to investigate the presence of bacterial DNA in synovial fluid, and to compare this with clinical and immunological findings in children with JIA, adults with persistent JIA, and adults with rheumatoid arthritis, in order to detect whether bacteria contribute to inflammation in TMJ arthritis. Synovial fluid and skin swab samples were collected from 30 patients (54 TMJs). Bacterial detection was performed using 16S rRNA pyrosequencing. Bacterial DNA was detected in 31 TMJs (57%) in 19 patients (63%). A positive statistically significant correlation was registered between bacterial DNA detected in TMJ synovial fluid and the following factors: total protein concentration in synovial fluid, interleukin 1β, tumour necrosis factor alpha, adrenocorticotropic hormone, and adiponectin, as well as the duration of the general medical disease. Fourteen different bacterial species were detected in synovial fluid. Bacterial DNA in TMJ synovial fluid without contamination was detected in more than 50% of the patients. Studies are needed to evaluate the consequences of this bacterial DNA in synovial fluid with regard to TMJ arthritis.

The Medical Faculty, University of Oslo writes: Recent studies demonstrate a variety of bacteria in TMJ patients with juvenile arthritis. It sends researchers in a new direction for how the disease can be treated, and perhaps even cured.

It is mentioned that it may be viable to swap out cortisone injections

A google translate article about the findings from the researcher: https://translate.google.com/translate?sl=auto&tl=en&js=y&prev=_t&hl=en&ie=UTF-8&u=http%3A%2F%2Fwww.odont.uio.no%2Fiko%2Fforskning%2Faktuelt%2Faktuelle-saker%2F2015%2Fnermer-seg-forklaring-pa-leddgikt.html&edit-text=


@Jonathan Edwards, what is your take on this? Is the researcher on the right path? Could it be right that the bacterias in the jaw trigger R.A?

Some studies have shown a strong correlation between ME and TMJ, could we hypothesise that bacterias in TMJ could trigger TMJ?

A systematic review of the comorbidity between Temporomandibular Disorders and Chronic Fatigue Syndrome.


http://www.ncbi.nlm.nih.gov/pubmed/26549386

 

[jimells]

"Central Sensitivity" again.

http://www.ncbi.nlm.nih.gov/pubmed/26549386

A systematic review of the comorbidity between Temporomandibular Disorders and Chronic Fatigue Syndrome.
Robinson LJ1,2, Durham J3, Newton JL4,5.

Abstract
The most common cause of chronic oro-facial pain is a group of disorders collectively termed temporomandibular disorders (TMDs). Chronic painful TMD is thought to be a 'central sensitivity syndrome' related to hypersensitivity of the nervous system, but the cause is unknown. A similar understanding is proposed for other unexplained conditions, including chronic fatigue syndrome (CFS).

 

[Marky90]

JE had a response to this paper earlier in this forum section