The below post by Rich in another thread explains shying away from the B6. I do think my friend has ammonia issues because he used to get so confused, moreso in the evenings. That had gone away, but last night it was back; he was on 3 multivitamins a day at one point before the new protocol and the confusion issues were gone so something in the multis & other supplements was helping methylation work better then is all I can figure. But it's good to know P5P is not so much an issue with ammonia, I will make sure he's getting enough of that. He was on 45 mg., now it's 7.5.
It just seems that many of the things that were eliminated or lowered from the Freddish protocol were things that apparently enhanced dopamine (D, B6, fish oil, multivitamin). I thought the swallowing (which needs dopamine) had gotten better with the re-addition of D, but was bad again last night, so I'm looking to go back on what we were before, but without any problem items i.e. iron, copper, calcium, B6. We sent in for his genes, but they won't be back for months of course. He was on high doses of things before with no mood swings. He's older. So now he REALLY doesn't believe this stuff is working, and I don't blame him, coupled with the fact that it's now difficult to swallow some of the pills. sigh.