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Amazingly, even a quarter tab of a-B12 allowed me to go out for a second time on the day I took it (normally can go out only once a day, if I'm lucky) - then 3/4 tab the next day also let me go out twice, with no PEM from the previous day; out for longer than normal the next day with 1 tab; and out for the longest walk I've had in about 9 months this morning even before my 1 tab. I hope this keeps up! No adverse symptoms yet. I'm assuming this isn't the Mg.
Two questions:
1. Should I keep upping my dose of a-B12? How will I know when I've gone too far?
2. I'm going to start on m-B12 next (the scary one) - my questions from the above post still apply. I daren't start until I know the answers!
Very pleased with what's happened so far.
Hi Sasha,
Equilibrium is reached with the adb12 for most people around 3mg a day or less on the average. The startup effects of adb12 are short lived and cease being part of the mb12 startup. So I would put it this way with adb12; it has dose related effects at 1-3000mcg for most people, a discontinuity as it no longer affects the body but doesn't impact the CNS yet, and then from about 30-60mg or maybe more sublingual for the CNS.
With mb12 the dose related effectiveness is in the range 1-20,000mcg sublingual, and 30-60mg sublingually for the CNS. When another 5mg tablet of mb12 makes no discernible difference at all stop increasing. Let that sit for a couple of weeks at that dose and then try the 50mg challenge dose to test for CNS effects.
Should I keep upping my dose of a-B12? How will I know when I've gone too far?
Your whole body will permanently change to dayglo magenta!
All kidding aside though, if you actually identify any genuine symptoms of "too much" you will actually be the first to do so. I have not ever so seen any such genuine symptoms. So far thing suggested as such has been low potassium, low folate, and other missing or low items. I recently finished an experimental trial of 180mg/day injections for a couple of months. While the results are complicated, there were no symptoms of any kind caused by that except continually lurid urine.
Thanks very much for this, Freddd, especially at the moment.
I'm taking Source Naturals dibencozide and my one tablet gives 8.6mg so I must be massively covered for the equilibrium dose unless I've got CNS/CFS problems. Is it possible to tell if I've got such problems from symptoms? I.e. are certain symptoms indicative of a CNS/CFS B12 deficiency as opposed to a tissue/serum deficiency? I can't get blood tests for this kind of thing here in the UK.
Sorry if I've missed a post on this - this thread is so enormous it's taking me a long time to work through it.
Pity you're kidding about going dayglo magenta - I've no objection to an entertaining symptom!
Hi Lena,
I would think that 1 3mg adb12 is entirely adequate while you start bringing mb12 on board. The balance between the two is important. With the mb12 and other factors it's effects will change. Balance is very important in all this.
Continuing to plough through the thread, up to #395 and noticed this. Am I wrong to keep piling on the a-B12 without starting m-B12? I'm up to 3 x 8.6mg tabs of a-B12 already and was planning to go up to a dose that would get to the CNS.
Continuing to plough through the thread, up to #395 and noticed this. Am I wrong to keep piling on the a-B12 without starting m-B12? I'm up to 3 x 8.6mg tabs of a-B12 already and was planning to go up to a dose that would get to the CNS.