I was just looking up to see if anybody was posting about pneumoniae infections causing ME/CFS / fibromyalgia etc. I have heard of these many times over the years but just saw a video from a doctor saying that based on when your symptoms started if you had mono then think Epstein Barr and if you had a lung infection then think Mycoplasma Pneumoniae or chlamydia pneumoniae.
EDIT: For me I think mine may have started after the worst lung infection of my life that lasted for months shortly after I started allergy immunotherapy shots and I had to stop them and never resumed them. It started out with a stiff neck and didn't get to fatigue and paresthesias and many other symptoms until a year after that and then progressed to muscle pain spreading and more fatigue.
I see that the poster mentions the antibiotics like doxycycline, rifampin and Bactrim. Another person mentions these plus azithromycin, which is actually the four I was taking for six months when I tried them. The doxycycline was low dose pulsed though. The doctor told me he was treating borrelia and maybe bartonella infection. I was doubtful, but I thought if I had any infection it didn't really matter if he didn't know as long as he had experience with results, which I wasn't even sure about that much.
I stopped after 6 months when he wanted me to continue for years or life I think. I started to get really bad paresthesias and bee sting pains all over my body which lasted for a few years after I stopped the antibiotics. They would last for about 18 months and then came back if I had an upper respiratory infection. Thankfully after about 5 years they stopped coming back even when I had upper respiratory infections.
I don't get upper respiratory infection in recent years and it may be due to supplementing with cholecalciferol, which is an important seco-steroid hormone for the immune system and many other things.
More recently I've been looking at doing the Coimbra protocol which is using 25/mcg per kg cholecalciferol of body weight over a period of a few years to treat auto-immune diseases. I also recently discovered Dr. Mark Gordon from
https://tbihelpnow.org and his work on brain inflammation and traumatic brain injuries and treating that with pregnenalone and Dehydroepiandrosterone (DHEA), which are two neuro-steroids. So, I'm planning on adding those two.
I did a quick search just now and found DHEA may be effective against Epstein Barr:
https://pubmed.ncbi.nlm.nih.gov/6268330/
And, something about DHEA on mycoplasma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725024/
These are both immunomodulatory and as Dr. Mark Gordon said can lower IL-6, though I've had that tested and it was not elevated. But here is a paper I just found talking about some immune effect:
https://pubmed.ncbi.nlm.nih.gov/12692147/
and also I found this on adrenal function related to pneumoniae infection outcome and DHEA is produced by adrenal.
https://erj.ersjournals.com/content/36/3/615
I also believe DHEA is used for B-Cells and I think they are involved in ME/CFS, though I think it may increase production and I think normally the idea is they should be temporarily wiped out because they are causing a problem.