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epinephrine 6.8 low
noreinephrine 19.4 low
dopamine 177.8 elevated
glycine 1665.6 elevated
glutamate 49 elevated
pea 82.4 elevated
thanks for any and all input.
regards, navid
I also got results recently and would love any thoughts on how they relate to glutathione:
SUBSTANCE - LEVEL (NORMAL RANGE)
DHEA - 324.0 (33.0-496.1)
Epinephrine - 7.7 (7-12)
Norpepinephrine - 29.5 (30-45) LOW
Dopamine - 171.5 (115-175)
Serotonin - 133.1 (120-185)
Glycine - 1,570.0 (455-980) HIGH
GABA - 6.8 (4.7-7.0)
Glutamate - 43.3 (15-32) HIGH
PEA - 35.3 (30-70)
Histamine - 18.6 (14-24)
Creatinine - 125.2 (28.0-259.0)
Low cortisol in the morning, staying pretty steady, and ending higher than it should.
From what I've read online (including a richvank document on the wiki), the elevated glycine and glutamate we both have are pretty interesting because they are two of the three components of glutathione. I also had high homocysteine in the past (5 years ago), which is a precursor of cysteine, the third component. Could this reflect that my underlying problem is a trouble converting homocysteine to cysteine, thereby interfering with glutathione production and causing those three to become elevated as they get "backed up" in the body?
Navid's values seem quite similar to mine, albeit his are a bit more extreme, aside from my PEA being pretty normal.
My doc had me start a couple supplements for my values, including taurine, 5-hydroxtryptophan, L-theanine, N-acetylcysteine, and alpha-lipoic acid. Included are co-factors, the most notable of which might be B-6, since I haven't specifically supplemented that before, and I think it's involved in processing homocysteine (along with folate and B12).
Something in the supplements is making a huge impact on my circulatory problems - no more light-headedness, even when standing in the kitchen for over an hour, etc, no freezing cold feet, no need to lie down a couple times per day. I'm still limited in muscle use though.
Hi, Valentijn.
I think your analysis is probably correct. B6 and magnesium are needed for the enzymes in the transsulfuration pathway, which converts homocysteine to cysteine, which in turn is usually the rate-limiting amino acid for the synthesis of glutathione. If glutathione is depleted, it can lead to depletion of vitamin C, also, and that is needed to convert dopamine to norepinephrine. I'm guessing that you are right about the B6 being responsible for your improvements. It makes sense to me, at least.
Rich
@Valentijn -- five years later(!) -- wondering if you came to the conclusion that it was b6 that was helping the circulation/cold feet issue?Great, thanks so much for your analyses (analysises?)!
It was a temporary improvement, albeit fairly dramatic. It slowly disappeared over the following month or two. I still do better with a B multi, I need magnesium for muscle twitches, and I do better (wiredness) if I take 1800mg NAC every day.@Valentijn -- five years later(!) -- wondering if you came to the conclusion that it was b6 that was helping the circulation/cold feet issue?
It's supposed to help with lung infections, due to breaking down mucus. Some people report gut problems, but I haven't had that issue.Any negatives -- or other positives -- from the NAC?
It's indeed a mucus breaking down, old remedy, I dont think it's prescribed a lot anymore.I do better (wiredness) if I take 1800mg NAC