Anyone here have lupus or Type 1 diabetes?

[sometexan84]

Was just curious why I don't see many people on here w/ Lupus (SLE) or Type 1 Diabetes. Then I thought maybe more have it than I realized?

I'm of the opinion that Enterovirus is the cause of a large portion of those w/ ME/CFS. And that Enterovirus is the primary cause of lupus and Type 1 diabetes as well. And chronic fatigue is huge in T1D and Lupus. So I thought, well if that is true, then why don't more people here on PR forum have Lupus (SLE) and T1D?

I was thinking maybe those diagnosed w/ T1D or Lupus might be less likely to find and join this forum because, well, they already know what's causing they're illness. Thoughts?

Just curious and hoping to gain further insight.

 

[Judee]

I have at least 2, maybe 3, people in my family with Lupus but my tests for it always come back negative.

 

[sometexan84]

When I had my HLA disease risk alleles tested, so I could find what diseases I'm genetically high risk for, I found that they were mostly Enterovirus related diseases (eg rheumatoid arthritis, lupus, T1D, etc)

I came to the conclusion that I must have a genetic tendency towards allowing Enterovirus (or similar) to form a constant presence in my body. So perhaps I have IFN signaling genes that are faulty or something along those lines

 

[Seadragon]

Not Lupus as tested negative for the specific antibody but I have low positive ANA, high positive RF and low positive ASMA and intermittent positive Sed Rate as well as significantly raised Calprotectin.

Never found out what is at the bottom of all this, just keep getting the ME diagnosis. I do have significant exhaustion and PEM (though in my case it is instant not next day) but believe there is more to my illness than that as I have many symptoms that cannot be attributed to ME alone.

Tested negative for enteroviruses many years ago though...

 

[Violeta]

When I had my HLA disease risk alleles tested, so I could find what diseases I'm genetically high risk for, I found that they were mostly Enterovirus related diseases (eg rheumatoid arthritis, lupus, T1D, etc)

I came to the conclusion that I must have a genetic tendency towards allowing Enterovirus (or similar) to form a constant presence in my body. So perhaps I have IFN signaling genes that are faulty or something along those lines

I realize you probably don't have Hep C, but this might extrapolate to other IFN issues.

https://pubmed.ncbi.nlm.nih.gov/27716962/

 

[sometexan84]

I don't have Hep, thank goodness

 

[Violeta]

I realize you probably don't have Hep C, but this might extrapolate to other IFN issues.

https://pubmed.ncbi.nlm.nih.gov/27716962/

"We conclude that Ach (acetaldehyde) disrupts IFNα-induced STAT1 phosphorylation by the up-regulation of USP18 to block the innate immunity protection"

Does this apply to other diseases, is why I linked it.

 

[L'engle]

A lupus diagnosis requires several tests to be positive. If you only have some autoimmune tests, you get... no diagnosis. It is all or nothing and I suspect leaves out a certain number of people who have autoimmunity but not enough to trigger all the tests.