Ok, so after 7 years of modifying my diet (wahls now) and experimenting with energy and detox supplements, I realize now that allergies / mast cells are still a problem for me despite avoiding all my known food
intolerances. I thought I had my allergies under control because the constant runny nose, itchy watery eyes, constant phlegm, etc were
eliminated when I removed the SAD garbage from my diet. Recent throat swelling should've been a clue for me but my cfs brain doesn't get clues anymore. Lol
I figured out several years ago that if I tried adding bacon or tomatoes back into my gfcfsf diet
that my fibro pain returned with a vengence. I wasn't sure why until I started reading about mast cells.
Cort has a great article here.
I've been on a low oxalate diet since 2008 due to kidney stones and not too long after eliminating
high ox foods my pelvic pain disappeared. I attrubuted this to eating high ox foods since that's what I'd read
on the trying low oxalate diet board and the vulvodynia site.
I've been experimenting with high ox foods for the last year
and discovered that I don't always react to high ox foods which makes me think mast cells are involved.
I've read that certain bacteria degrade oxalates but if there's a connection I haven't made it yet. I've been eating
Kefir or taking probiotics most days since 2005. The connection could be there tho and I just haven't
found it.
I passed 1 kidney stone in the last year while experimenting with high ox foods but I'm pretty sure
that was from not drinking enough water. I was on a veggie juicing and orange kick at the time so I didn't feel thirsty.
Back to my allergies .. According to a skin prick test years ago, I'm allergic to most everything on the planet.
I'm extremely allergic to dust (huge welt on back during testing) and I know I can never keep my place dust free because
I'm allergic to dust so dusting makes me feel sick. Lol . I'm working in this tho. I put away all knick knacks.
I've been using Target brand children's dye free benadryl and it works for the throat swelling but it wipes me out. I tried 25 mg of Vistaril
for the first time the night before last and slept all day yesterday. It was a new and interesting feeling in my
brain so I'm going to try it again. I think. I'm not sure how to define the feeling just yet. Drugged yes but not like
Loratab or klonopin.
I was wondering if others here experienced the "funky" brain feeling from Vistaril. I skipped it last night because I was afraid to take it. I had ataxia 24/7 from 1990 - 2006 and I get myoclonus and petite mals easily so my brain isn't what it should be.
Meanwhile if I can stay awake today I want to go get some stinging nettle, quercitin, claritin and zantac.
Anyone else with me/cfs treating these ? Tx .. X
Eta. I recognized this groggy / post Vistaril feeling. It's the same way I feel for a few days after iv sedation.
I have read in multiple places that CITRATE inhibits stones. I admit I do not eat spinach very often as it is a known oxalate, but I do not in any other way deliberately avoid oxalates. In fact - aren't they high in tea? I have drunk tea like a fish for long periods of time (like a year) with no problem. I have taken high dose cal/mag supplements lifelong with no stones. I've had stone-formers warn me and scoffed, telling them I seem to be a sieve for cal/mag and the miracle would be if I ever get enough to make a stone. Whatever the reason, I've never had one.
Rand56 told me it was citrate and I have ALWAYS favored the citrate form of cal/mag (I can in some subtle way feel the difference).
So for instance you can find studies like this:
J Urol. 1985 Jul;134(1):20-3.
Prevention of recurrent calcium stone formation with potassium citrate therapy in patients with distal renal tubular acidosis.
Preminger GM,
Sakhaee K,
Skurla C,
Pak CY.
Abstract
Distal renal tubular acidosis is a common cause of intractable calcium nephrolithiasis. We examined the effect of oral potassium citrate therapy in 9 patients with incomplete distal renal tubular acidosis diagnosed on the basis of an abnormal response to an oral ammonium chloride load. Patients were studied during a control phase and after 3 months of potassium citrate treatment (60 to 80 mEq. daily). Potassium citrate caused a significant increase in urinary pH and urinary citrate, and a decrease in urinary calcium. The urinary relative saturation ratio of calcium oxalate significantly decreased during treatment, while that of brushite did not change. Potassium citrate also was shown to inhibit new stone formation. During a mean treatment period of 34 months none of the 9 patients had new stones, although 39.3 plus or minus 79.7 (standard deviation) stones per patient formed during the 3 years preceding treatment. The results support the potential clinical advantage of potassium citrate therapy in patients with distal renal tubular acidosis and recurrent calcium nephrolithiasis.
Cell Biology – Immunology – Pathology
Kidney International (2004)
65, 1724–1730; doi:10.1111/j.1523-1755.2004.00566.x
Citrate inhibits growth of residual fragments in an in vitro model of calcium oxalate renal stones
Karyee Chow, James Dixon, Sally Gilpin, John P Kavanagh and Popduri N Rao
Department of Urology, South Manchester University Hospital, Manchester, United Kingdom
Correspondence: Dr John P. Kavanagh, Department of Urology, Education and Research Centre, South Manchester University Hospital, Wythenshawe, Southmoor Road, Manchester, M23 9LT, UK. E-mail:
Johnk@fs1.with.man.ac.uk
Received 20 August 2003; Revised 28 October 2003; Accepted 3 December 2003.
Top of page
Abstract
Citrate inhibits growth of residual fragments in an in vitro model of calcium oxalate renal stones.
Background
Alkaline citrate is thought to be helpful in reducing recurrences of calcium oxalate stones. The evidence for this is incomplete, there have been few good trials, all with their own limitations, and not all reported any significant benefit. In vitro studies are usually cited to support the clinical studies but these too have their drawbacks, in particular they relate to crystals and microscopic aggregates and not to actual stone growth. Here we test citrate in vitro using a model of macroscopic calcium oxalate stone enlargement.
Methods
Twelve calcium oxalate stones were grown at a time in a stone farm. Six were grown with 2 mmol/L citrate and six with 6 mmol/L citrate. Three protocols were tested; artificial urine, artificial urine with urinary macromolecules (UMM) from male controls and artificial urine with UMM from male stone formers. The stones were grown continuously for at least 24 days.
Results
In all three experiments the higher citrate concentration significantly reduced the growth rate of stones by more than 50% (
P < 0.001). There was a small decrease in ionised calcium in the stone growth media (
P < 0.001) and significant (
P < 0.001) but small increase in pH (about 0.07 pH units). The inclusion of UMM also brought about a decrease in stone growth, particularly at 2 mmol/L citrate.
Conclusion
Citrate inhibited stone growth in this laboratory model. This was true both in defined media and with addition of UMM. This adds to evidence justifying the use of alkaline citrate in calcium oxalate nephrolithiasis.
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http://www.cmaj.ca/content/174/10/1407.short#T1
This is a really good paper that goes over all factors in oxalate stone formation