NotThisGuy
Senior Member
- Messages
- 312
I think my whole live i have trouble with my adrenals. Maybe it was because of chronic infections like fungus and borrelia, maybe genetics or maybe something else.
10 years ago i was diagnosed with IBS-D.
Since 1 year my adrenals are a true mess now and i developed CFS.
I read a lot about adrenal fatigue theories and how to treat it and lot of people came to the conlcusion that the adrenal fatigue theory is false and it's just a downregulation of the HPA-axis.
I tried to find a way to boost this axis and tried all the common herbs recommended for upregulation of the HPA-axis. Nothing worked so far.
I found this interesting study among a lot of others that came to the conclusion, that methionine and leucin boosts the HPA-axis:
https://www.ncbi.nlm.nih.gov/pubmed/9269123
"These results indicate that both met- and leu-enkephalin increase the activity of the HPA axis in rats and both central opioid and adrenergic alpha-receptors are involved in this stimulation."
(How do i mage this look like an quote window?)
Another study says, that methionine and leucin increased corticosterone but not ACTH.
https://books.google.de/books?id=D0yeBQAAQBAJ&pg=PA462&lpg=PA462&dq=leucine corticosterone&source=bl&ots=7ziHrXuUMM&sig=WRchDwXbeHSY3ARFMnCgVdSepAo&hl=de&sa=X&ved=0ahUKEwiIpqPdw_HSAhXKhiwKHR9pD3w4ChDoAQheMAg#v=onepage&q=leucine corticosterone&f=false
There are more studies regarding leucin and methionine and corticosterone and HPA-axis.
Both methionine and leucin is doing something.
I have a salt intolerance and my adrenals are so weak by now that i have constant fear my heart is stopping anytime soon. I also developed POTS and orthostatic dyspnea.(to this point where I was gasping for air like a fish, really scary)
Leucin and methionine both give my a little craving for salt, but i still am really thirsty and cant tolerate sodium.
Leucin and methionine reduced my PEM.
Allthough methionine worsened my dyspnea a bit.
I only tried micro-doses of both. (Maybe 1mg of each, maybe less)
The dyspnea gets better after some licorice. Maybe cortisol depended dyspnea?
Right now im asking myself, what if it's not just a downregulation of the HPA-axis? What of we truely are way too deficient in nutrients, so the adrenals just can't produce the hormones? (@Freddd's refeeding syndrome)
This theory shouldn't be big news to everyone since a lot of people support this theory.
I tried vit. B5 for 1-2 months and it truely gave me a boost before i crashed. So maybe whatever pathway uses B5 to produce adrenal hormones just got way to deficient in other nutrients? but which nutrients?
Im specifically interested in those pathways that includes the renine-angiotensine-system.
My renine is way to high so the problem can't be there.
My ACE (angiotensin-converting-enzyme) is low and my angiotensin II is also low.
Since @Lolinda stated that POTS gets better with acetylcholine the next thing to try might be serine, which is necessary for acetylcholine production.
Anyone here with adrenal fatigue and POTS or hypotonic problems who has a blood panel /urine panel of aminoacids?
Since i tried every vitamin possible the problem might be deficient aminoacids
10 years ago i was diagnosed with IBS-D.
Since 1 year my adrenals are a true mess now and i developed CFS.
I read a lot about adrenal fatigue theories and how to treat it and lot of people came to the conlcusion that the adrenal fatigue theory is false and it's just a downregulation of the HPA-axis.
I tried to find a way to boost this axis and tried all the common herbs recommended for upregulation of the HPA-axis. Nothing worked so far.
I found this interesting study among a lot of others that came to the conclusion, that methionine and leucin boosts the HPA-axis:
https://www.ncbi.nlm.nih.gov/pubmed/9269123
"These results indicate that both met- and leu-enkephalin increase the activity of the HPA axis in rats and both central opioid and adrenergic alpha-receptors are involved in this stimulation."
(How do i mage this look like an quote window?)
Another study says, that methionine and leucin increased corticosterone but not ACTH.
https://books.google.de/books?id=D0yeBQAAQBAJ&pg=PA462&lpg=PA462&dq=leucine corticosterone&source=bl&ots=7ziHrXuUMM&sig=WRchDwXbeHSY3ARFMnCgVdSepAo&hl=de&sa=X&ved=0ahUKEwiIpqPdw_HSAhXKhiwKHR9pD3w4ChDoAQheMAg#v=onepage&q=leucine corticosterone&f=false
There are more studies regarding leucin and methionine and corticosterone and HPA-axis.
Both methionine and leucin is doing something.
I have a salt intolerance and my adrenals are so weak by now that i have constant fear my heart is stopping anytime soon. I also developed POTS and orthostatic dyspnea.(to this point where I was gasping for air like a fish, really scary)
Leucin and methionine both give my a little craving for salt, but i still am really thirsty and cant tolerate sodium.
Leucin and methionine reduced my PEM.
Allthough methionine worsened my dyspnea a bit.
I only tried micro-doses of both. (Maybe 1mg of each, maybe less)
The dyspnea gets better after some licorice. Maybe cortisol depended dyspnea?
Right now im asking myself, what if it's not just a downregulation of the HPA-axis? What of we truely are way too deficient in nutrients, so the adrenals just can't produce the hormones? (@Freddd's refeeding syndrome)
This theory shouldn't be big news to everyone since a lot of people support this theory.
I tried vit. B5 for 1-2 months and it truely gave me a boost before i crashed. So maybe whatever pathway uses B5 to produce adrenal hormones just got way to deficient in other nutrients? but which nutrients?
Im specifically interested in those pathways that includes the renine-angiotensine-system.
My renine is way to high so the problem can't be there.
My ACE (angiotensin-converting-enzyme) is low and my angiotensin II is also low.
Since @Lolinda stated that POTS gets better with acetylcholine the next thing to try might be serine, which is necessary for acetylcholine production.
Anyone here with adrenal fatigue and POTS or hypotonic problems who has a blood panel /urine panel of aminoacids?
Since i tried every vitamin possible the problem might be deficient aminoacids
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