- Messages
- 65
Hi All,
I'd really appreciate some help. After building in all the supports, including lithium, which was non-existent in my hair, my treatment isn't going well. I started hydroxocobalamin on Sunday, and have since increased that to 500mcg per day (a small amount, I know). I started adb12 at 1g on Tuesday, and found a nice "neuro" effect, but stopped that yesterday to focus on getting methylfolate on board. So, I took a mere 100mcg of methylfolate with my hb12 this morning; and this afternoon I've experienced some violent diarrhea; am feeling very low and confused; am experiencing stomach pains; some pins and needles (especially in my face); have experienced panic attacks a few times; and am generally feeling lethargic. I want to believe this is detox kicking in -particularly since I've felt only minor detox from the hb12 up until now, and that's since stopped - but I'm also aware that I'm not taking mb12, and the addition of methylfolate might have induced an episode of paradoxical folate deficiency, even from such a small amount. (The only thing I added in today was 25mg of niacinamide at lunch.) Any thoughts on this would be greatly appreciated ...
If I do have PFD, I suspect the advice will be to stop the methylfolate (for now) and hb12, and start mb12. However, you'll see from my snp's that I'm COMT++/FDR Vaq +-, so I don't tolerate methyl groups well. In fact, I have a history of mood swings, and even a cup of coffee makes me feel hypo-manic. With that said, I have been able to take 1g of ALCAR for the last week, and apart from some head rushes, it's been manageable. Conversely, the MTRR++ status means I'm probably not converting much of the hb12. So, I feel like I'm in a real tight spot genetically! That said, I'm really hoping I can work through this, even if the wise counsel is to go low and slow.
Thanks a lot,
Leon
I'd really appreciate some help. After building in all the supports, including lithium, which was non-existent in my hair, my treatment isn't going well. I started hydroxocobalamin on Sunday, and have since increased that to 500mcg per day (a small amount, I know). I started adb12 at 1g on Tuesday, and found a nice "neuro" effect, but stopped that yesterday to focus on getting methylfolate on board. So, I took a mere 100mcg of methylfolate with my hb12 this morning; and this afternoon I've experienced some violent diarrhea; am feeling very low and confused; am experiencing stomach pains; some pins and needles (especially in my face); have experienced panic attacks a few times; and am generally feeling lethargic. I want to believe this is detox kicking in -particularly since I've felt only minor detox from the hb12 up until now, and that's since stopped - but I'm also aware that I'm not taking mb12, and the addition of methylfolate might have induced an episode of paradoxical folate deficiency, even from such a small amount. (The only thing I added in today was 25mg of niacinamide at lunch.) Any thoughts on this would be greatly appreciated ...
If I do have PFD, I suspect the advice will be to stop the methylfolate (for now) and hb12, and start mb12. However, you'll see from my snp's that I'm COMT++/FDR Vaq +-, so I don't tolerate methyl groups well. In fact, I have a history of mood swings, and even a cup of coffee makes me feel hypo-manic. With that said, I have been able to take 1g of ALCAR for the last week, and apart from some head rushes, it's been manageable. Conversely, the MTRR++ status means I'm probably not converting much of the hb12. So, I feel like I'm in a real tight spot genetically! That said, I'm really hoping I can work through this, even if the wise counsel is to go low and slow.
Thanks a lot,
Leon