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wellbutrin/bupropion lowers TNF in crohns

Discussion in 'Other Health News and Research' started by heapsreal, Oct 8, 2012.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    australia (brisbane)
    Posting this as auto immune drugs are used for this same purpose but with wellbutrin, people may have it more available. http://www.ncbi.nlm.nih.gov/pubmed/16644475

    In a wide range of human diseases of inflammatory nature like Crohn's disease, pathology is mediated in part by pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF) or interferon-gamma. We show here that a commonly used generic antidepressant bupropion, in wide use worldwide to treat depression in humans for a decade now, profoundly lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model. Mice challenged with an otherwise lethal dose of LPS were protected by bupropion and levels of the anti-inflammatory cytokine interleukin-10 were increased. Previous data in rodents and humans indicate antidepressant effects of bupropion are mediated by its weak reuptake inhibition of norepinephrine and dopamine. Concordant with this, TNF suppression by bupropion in our mouse LPS model was largely abrogated by beta-adrenergic or dopamine D1 receptor antagonists but not by a D2 antagonist. TNF synthesis is controlled by an inverse relationship with intracellular cyclic adenosine monophosphate (cAMP) and stimulation of either beta-adrenoreceptors or D1 dopaminergic receptors result in increased cAMP but stimulation of D2 receptors lowers cAMP. We conclude that bupropion may suppress TNF synthesis by mediating increased signaling at beta-adrenoreceptors and D1 receptors, resulting in increased cAMP that inhibits TNF synthesis. Bupropion is well tolerated also in non-psychiatric populations and has less risk with long term use than current anti-inflammatory, immunosuppressive or TNF suppressive treatments such as prednisone, azathioprine, infliximab, or methotrexate. New anti-inflammatory treatments are needed. We believe a new chapter in antiinflammatory, TNF lowering treatment of disease has been opened. Bupropion's use for this in humans should be explored.
    nanonug likes this.
  2. nanonug

    nanonug Senior Member

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    Virginia, USA
    Excellent news! Wellbutrin XL is a drug a keep recommending on this site.
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    I posted this as i wonder if the positive effects people are getting arent from its antidepressant action but maybe its anti-inflammatory action,
  4. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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  5. beaverfury

    beaverfury beaverfury

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    West Australia
    My doctor insisted bupropion wasnt available in Aus except as a zyban patch. Of course, this is easily fixed by ordering
    online. But would be cheaper on benefit scheme.

    It seems to have a reputation for making people a little irritable. Can anyone speak of their experience with it?
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    For us aussies its way cheaper ordering it online and wouldnt be covered on the PBS as its not indicated for depression here only to stop smoking, maybe need to 'give up' smoking ;) . Dosage i used was only 75mg, i did try 150mg but didnt notice any difference to the lower dosage. These were slow release tablets but were ok to cut in half. I havent looked at online sources/prices for this in awhile so cant give much info there.

    cheers!!!
    beaverfury likes this.

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