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FDA says one type of generic Wellbutrin XL antidepressant is ineffective

Discussion in 'Other Health News and Research' started by ggingues, Oct 7, 2012.

  1. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
  2. alex3619

    alex3619 Senior Member

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    Oh how can this be? All generics are equal aren't they?

    Its nice the see the FDA caught this one.
    ggingues likes this.
  3. jimells

    jimells Senior Member

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    What a CYA statement! It's like a quit-claim deed to the Brooklyn Bridge: "Any claim I may have to the Bridge is now yours"

    I found Welbutrin to be effective... at causing nightmares. When are these people going to get a clue about how useless these drugs are, except for generating big profits? Yes, I know they are as effective as placebos, and if a placebo works, that's great for the patient. But I've never heard of placebos causing the long list of serious adverse effects attributed to antidepressants.
    ggingues likes this.
  4. nanonug

    nanonug Senior Member

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    I know several people who take Wellbutrin with very good results and no nightmares. I am curious, what dosage and how long did you take this?
  5. penny

    penny Senior Member

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    Seriously? Wow. The logic does escape me. It didn't work for you and so "these drugs" are only placebo. Anyway...

    Personally, I had very good results with the brand name Welbutrin (this was FOR depression not CFS/ME), but reacted very badly to one of the early generics - more depressed than I had started within a week of the switch, and when I went back to the brand name I bounced back very quickly. The only side effect I had on the brand name was dry mouth - otherwise I felt clear headed and like myself.

    I've also found that the different manufacturers of ambien turn out very different results. I know there's one generic that works well for me, then the brand is a close second and then at least two generics that really leave me feeling more wired and tired but not able to sleep. I'm glad the FDA is making even a limited acknowledgement of the variability.

    My 2cents - not all generics are bad, but it's quite possible for all 'brands' to be different. Buyer be aware :)
  6. jimells

    jimells Senior Member

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    I carefully re-read my post several times, and I fail to see where I stated, "these drugs don't work for me, therefore they are only placebo."

    Folks on this forum like to see statements that are backed up by published research, so here goes:

    These references and quotes are from Surviving America's Depression Epidemic, Bruce E. Levine, Ph.D, Chelsea Green Publishing, 2007
  7. penny

    penny Senior Member

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    It doesn't sound like you're comparing apples to apples though. While Wellbutrin/buproprion is classed as an antidepressant that does not mean that antidepressant=buproprion.

    My understanding is that buproprion does not fall into any of they classic antidepressant classes (SSRI or tricyclic) and in fact is described as 'atypical'. A brief bit from Wikipedia:
    The first reference you give compares placebo results in a St. Johns Wort group with patients treated with Zoloft (not buproprion).

    The Second is about a host of other antidepressants, but again NOT buproprion:


    The third reference I can't find the original source article without signing up for a membership to Psychiatric Times, which I don't want to do but considering the date of publication I suspect it also is looking at the earlier classes of antidepressants.

    We probably don't totally disagree, I do think antidepressants are generally pretty crap (I actually think they are potentially dangerous) and VERY over prescribed (for dubious reasons) but I would not go so far to say that all of any class of medications are JUST placebo's. I believe brain chemistry is very badly understood and the balance and imbalances of neurotransmitters are very unique, and so I think it takes the right med lining up with the right (or wrong) imbalance at the right time to have positive results. I guess I just think these things are much more complex than "all of x" are "y".
  8. IreneF

    IreneF Senior Member

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    Cymbalta keeps me out of the psych ward.
    penny likes this.

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