Dr. Bateman answers IOM questions from the community: Part 2
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FDA says one type of generic Wellbutrin XL antidepressant is ineffective

Discussion in 'Other Health News and Research' started by *GG*, Oct 7, 2012.

  1. *GG*

    *GG* Senior Member

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    Concord, NH
  2. alex3619

    alex3619 Senior Member

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    Oh how can this be? All generics are equal aren't they?

    Its nice the see the FDA caught this one.
     
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  3. jimells

    jimells Senior Member

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    What a CYA statement! It's like a quit-claim deed to the Brooklyn Bridge: "Any claim I may have to the Bridge is now yours"

    I found Welbutrin to be effective... at causing nightmares. When are these people going to get a clue about how useless these drugs are, except for generating big profits? Yes, I know they are as effective as placebos, and if a placebo works, that's great for the patient. But I've never heard of placebos causing the long list of serious adverse effects attributed to antidepressants.
     
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  4. nanonug

    nanonug Senior Member

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    I know several people who take Wellbutrin with very good results and no nightmares. I am curious, what dosage and how long did you take this?
     
  5. penny

    penny Senior Member

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    Seriously? Wow. The logic does escape me. It didn't work for you and so "these drugs" are only placebo. Anyway...

    Personally, I had very good results with the brand name Welbutrin (this was FOR depression not CFS/ME), but reacted very badly to one of the early generics - more depressed than I had started within a week of the switch, and when I went back to the brand name I bounced back very quickly. The only side effect I had on the brand name was dry mouth - otherwise I felt clear headed and like myself.

    I've also found that the different manufacturers of ambien turn out very different results. I know there's one generic that works well for me, then the brand is a close second and then at least two generics that really leave me feeling more wired and tired but not able to sleep. I'm glad the FDA is making even a limited acknowledgement of the variability.

    My 2cents - not all generics are bad, but it's quite possible for all 'brands' to be different. Buyer be aware :)
     
  6. jimells

    jimells Senior Member

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    I carefully re-read my post several times, and I fail to see where I stated, "these drugs don't work for me, therefore they are only placebo."

    Folks on this forum like to see statements that are backed up by published research, so here goes:

    These references and quotes are from Surviving America's Depression Epidemic, Bruce E. Levine, Ph.D, Chelsea Green Publishing, 2007
     
  7. penny

    penny Senior Member

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    It doesn't sound like you're comparing apples to apples though. While Wellbutrin/buproprion is classed as an antidepressant that does not mean that antidepressant=buproprion.

    My understanding is that buproprion does not fall into any of they classic antidepressant classes (SSRI or tricyclic) and in fact is described as 'atypical'. A brief bit from Wikipedia:
    The first reference you give compares placebo results in a St. Johns Wort group with patients treated with Zoloft (not buproprion).

    The Second is about a host of other antidepressants, but again NOT buproprion:


    The third reference I can't find the original source article without signing up for a membership to Psychiatric Times, which I don't want to do but considering the date of publication I suspect it also is looking at the earlier classes of antidepressants.

    We probably don't totally disagree, I do think antidepressants are generally pretty crap (I actually think they are potentially dangerous) and VERY over prescribed (for dubious reasons) but I would not go so far to say that all of any class of medications are JUST placebo's. I believe brain chemistry is very badly understood and the balance and imbalances of neurotransmitters are very unique, and so I think it takes the right med lining up with the right (or wrong) imbalance at the right time to have positive results. I guess I just think these things are much more complex than "all of x" are "y".
     
  8. IreneF

    IreneF Senior Member

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    Cymbalta keeps me out of the psych ward.
     
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