Hi, All. I've played around with low doses of methyl b12 (1-2mg) and methylfolate (800mcg) for the past six months and noticed no effects. Five days ago, I started taking 15mg methyl b12 (5mg 3x/day, by Jarrow) and was hit with HUGE drowsiness by the second day. It feels like I swallowed a lot of benadryl or melatonin supplements. The drowsiness is day and nighttime. Part of me thinks it's a good thing (the sedation has taken my wired anxiety down quite a bit), so haven't backed down. I'm not taking any methylfolate, but plan to start it this weekend, and add in dibencozide and LCF over the next 7-10 days. Is this a side effect saying to continue or is it saying to back down? I don't really want to back down because I feel it is helping -- I'll take the sleep! And I also feel like I'm not crashing from walking across my apartment. I think I am much less weak. I don't know my genetic mutations -- hoping to get those in early 2015. I take a good food-based multivitamin and mineral supplement (Megafood) and Jarrow's B-Right (switching to Thorne once this bottle empties). I also supplement with additional electrolytes daily because i use frequent sauna and epsom salt baths. I'm going to have extra potassium on hand as I ramp up the other supps. I eat a whole foods, mostly organic diet that is free of gluten, dairy, and sugar with limited grains. I can't add in all individual supplements without feeling VERY overwhelmed, so trying to keep as simple as possible. I have had very severe CFS (no pain) for five years, with gradual onset the decade prior. I haven't had refreshing sleep in many years and I do have a lot of cerebral vasculitis from SPECT scans. I am mostly bedbound and have caregivers. Reading long paragraphs, watching tv, and writing are difficult. It is difficult for me to converse -- especially any type of planning conversations. I have to take many precautions when looking at a screen due to overstimulation (where blue blocker glasses, use f.lux, etc). I am also doing Dr. Brewer's antifungal protocol for mold toxicity (started three months ago). I'm hoping these two things can work synergistically. I don't see Dr. Brewer again until early 2015 so I am doing this without a doctor's support and that does scare me a bit. I don't want to end up on the other end of the bell curve -- so much b-vitamins that I become deficient in other things. A year ago, I almost ended up in the ER after two months on vitamin D supp (just 2,000iu/day). I know Vit D is different beast than B12, but I still want to be extra careful. Since I can't read or look at screens well, filtering through all of @Freddd's and Rich's posts is overwhelming. I love what I have been able to read and I am so grateful for their contributions, along with all of the posts from other followers of methylation protocols.