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Really nasty cold after starting methylation supps

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by whodathunkit, Feb 17, 2014.

  1. whodathunkit

    whodathunkit Senior Member

    So I started taking some methylation supps a few weeks ago (mB12, methylfolate). But I didn't get the Anabol Naturals Dibencoplex Solgar, or LCF until middle of last week or so.

    Overall I felt much better, but adjusted methylfolate for a bit of spaciness and irritability, and some minor "alternating poop issues". Also minor edema around my ankles. But I've gotten that from time to time for a while. I have some blood sugar issues I'm working on, as well.

    Then yesterday morning I felt great. Even-tempered, good energy, etc. But while I was exercising I noticed my nose was really, really runny. Which is very weird, because I don't have allergies and my nose almost never runs. Even when I get a virus I usually get a "yin" type cold where the congestion just stays in my head and won't come out. The virus runs its course without me ever expelling anything. I haven't had a "yang" runny-nose type cold in over 20 years. I chalked it up to partial methyl block and upped my methylfolate again.

    Yesterday afternoon it became clear I wasn't feeling well at all. Runny nose, sneezing, generally out of sorts. I didn't sleep well last night because my nose kept blocking up.

    Today I feel like crap and still having runny nose and sneezy issues. And I'm really tired. Little edema around my ankles.

    No post-workout soreness from yesterday's workout (D-ribose seems to take care of that pretty well).

    My question: is this a partial methyl block? Or (to paraphrase the good doctor Sigmund) is sometimes a cold just a cold?
  2. whodathunkit

    whodathunkit Senior Member

    I've pretty much answered my own question now, for anyone who might be interested.

    I seriously upped my folate, just to see what would happen. I was taking about 4 mg on Saturday, 7 on Sunday, and yesterday I was up to 10 mg, last dose around 10p. By the time I fell asleep around 1a this morning, my runny nose and nasal blockage was gone, without any OTC cold meds. I've taken nothing to try to alleviate my symptoms except supplements.

    What sleep I got was great, although the runny nose/blockage came back this morning around 5:30a and awakened me.

    But today, despite being sleep deprived, I feel better overall, and my "alternating poop issues" are resolved. The minor edema around my ankles is more minor still (almost gone). I plan to up my folate dosage a couple more mg today to see if that can't rid me of my symptoms entirely.

    I guess I am in worse shape than I thought, if this much methylfolate is of benefit to me. :-|
    Star-Anise likes this.
  3. Star-Anise

    Star-Anise Senior Member

    thanks for posting @whodathunkit
    I'm in the same position. I get these detox-y symptoms & edema & so far, when I up my methylfolate they tend to disappear. Seems we ware doing the folate dance together :) xoxo S
  4. Freddd

    Freddd Senior Member

    Salt Lake City

    HI Whodathunkit,

    You've got me thinking. Lack of b12/folate can cause very thick sticky congealed mucous, gums up sinuses, makes for raspy voice. Right after I get started, before Metafolin was easily available, I had a two week "cold" with a sore throat, not at all typical of what colds had been like for me. A lot of people have mentioned this. In the folate deficiency list "flu like symptoms" are mentioned. Maybe that should be modified to include "cold like symptoms". What do you think.
  5. whodathunkit

    whodathunkit Senior Member

    @Star-Anise :thumbsup: It's a lot more vigorous dance than I thought it was going to be. Frankly, I'd rather learn to foxtrot. LOL

    Freddd, my mucous has been more thin and runny, but there's a lot of it. My eyes are itchy, red, and watery, nose frequently itchy, sneezy, and runny, sinuses *hurt*. I don't have allergies but have had "bad" sinuses since the '80's (sadly, for all the '80's reasons). I'm inclined to view this as a healing problem rather than just one of the viruses that are going around my area primarily because of the profound effect on my sinuses.

    I'm coughy, but it's not hacky or productive. Comes and goes. Throat is sore but not real bad. Voice is definitely raspy. Thankfully, however, the congestion (that awful feeling where one or both nostrils is blocked and you can't breathe, especially when lying down) has not returned, and I haven't used any nasal decongestant. I'm trying to stay away from that because I've because I don't want to inhibit healing symptoms.

    Definitely not a typical cold for me at all.

    Worth noting is I definitely seem to feel better (symptoms clear more) right after I take a dose of methylfolate (like now). Also, I'm not entirely sure I haven't run a fever, but I don't have a thermometer so haven't checked. Sometimes I've felt like I had one.

    If atypical cold symptoms seem to be a reported pattern in paradoxical methylfolate deficiency then maybe it would be helpful to people if you added that to your deficiency symptoms list.

    I'm upping to 15g mfolate/day today. If my understanding is correct, there really is no upper limit of dosage, right? Except maybe what your wallet can support. LOL
  6. vortterx



    Hi! I know your original post was more than a year ago, so I hope you're still reading this.

    Just like you I'm experiencing cold/flu like symptoms which are atypical for me, after starting on methylb12 and methylfolate.

    My typical cold starts with a sore throat, then congested nose and deep, productive cough, and never to a fever. This time around it skipped the sore throat, was super runny (which could not be helped by antihistamines, strangely, as I usually respond very well to antihistamines) and a fever! I never get fevers, so I'm fairly convinced this isn't a typical cold.

    Prior to the cold I started Enzymatic Therapy B12, working up from 1mg to 5mg in over a week. I felt great. No issues. Then I added methylfolate just 400 mcg, and then 800mcg daily. I noticed that the higher the dose, the worse the symptoms.

    Yesterday I went a day without methylfolate and the cold symptoms improved greatly. Today I added 200mcg and back comes the mucous in my airways.

    I do also use potassium supplements but not adb12 and LCF yet (on the way). Just wondering what these cold symptoms indicate, and how I should adjust my methylfolate dosage?

    I appreciate any and all suggestions. Thank you.
  7. silverseas2014


    I also have had similar cold-like symptoms during Methylation Protocol---I have been taking the DQ (plus Potassium and Lithium Orotate) since last December. It seems that when I hit these bumps (ie. cold/flu-like symptoms) in the road --that they are always improved by increasing my doses of MethylB12 and Methylfolate (my doses for Dibencozide and L-Carnitine Fumarate hold steady).

    Right now, I am on 36 mg. of Methylfolate a day (broken into two doses of 18 mg morning and noonish) plus a commensurate amount of MethylB12.

    I have experimented quite a lot in the last 6 months. When deficiency symptoms appeared, I initially was afraid to up my doses. But when I hesitated or backed off on my doses, I always felt worse. So, now, if deficiency symptoms arise, I usually up my dose by 4 mg. and give myself 24 hours to see if the symptoms subside. The last two weeks, I have plateaued at the 36 mg./day of Methylfolate. --I should add that at the lower doses of Methylfolate, if I felt the deficiency symptoms, I would double the dose (2 mg. to 4 mg./4mg. to 8 mg./8 mg. to 16 mg.) but after 16 or so I would simply go up about 4 mg. at time.

    I feel good at the above doses. Good (not great) energy. Since I began the Methylation Protocol last December, I have not had a cold or sinus infection--which have been chronic for many years. I attribute my improving robustness to the DQ.

    In good health,
    vortterx likes this.

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