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Reaction to anesthesia

Discussion in 'General ME/CFS Discussion' started by Prosons, Oct 10, 2013.

  1. Prosons

    Prosons

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    Hello,
    Can anyone point towards any scientific documents regarding the adverse effects of anesthetics for CFS/ME patients? Why does this phenomenon occur? Is it a sensitivity because of a hyper-aroused sympathetic nervous system?

    Thank you,
    Frank
     
  2. Shell

    Shell Senior Member

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    Hummingbird has this. I doubt if there's much out there on ME and anesthesia as there's so little research on ME/Cfs overall.
    There does seem to be a lot of info about the bad effects of particularly general anesthetic on people with dysautonomia. As it seems (despite Ramsay) that various dysauto things seem co-mobid with ME maybe it's worth looking there - Dysautonomia Prison has some papers.

    I've had surgery 5 times since being ill - one GA with intubation which went a bit wrong - probably because of my jaw lock.
    Two GAs without intubation which went ok and two spinal's. The second one was fine but the first one suddenly switched off half way through- not nice. Managed a top up rather than GA and did ok.
     
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  3. Gloria H

    Gloria H

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    http://en.wikipedia.org/wiki/Laughing_gas
    in it's Nero-toxicity section & references might be a place to start your search.
    Blessings to you
     
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  4. shannah

    shannah Senior Member

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    Here is a link which includes links to the original papers

    http://www.ncf-net.org/patient-physician.htm

    Anesthesia
    Information about anesthesia
    Anesthesia has adversely affected patients with CFIDS (also known as chronic fatigue syndrome and myalgic encephalomyelitis). The reason for this has been found. Recent research* funded by the National CFIDS Foundation, Inc. found that a substance, much like ciguatera toxin, is being produced in the body by a disease process in those with CFIDS/ME/CFS. Dubbed the “ciguatera epitope,” this research explains the danger of using any anesthesia that uses the sodium channel at the cellular level. Some anesthesiologists have had success blocking the sodium channel during anesthesia for CFIDS/ME/CFS patients.
    *J Clin Lab Anal, 6/2003, Hokama et al
    *J Toxicology, 12/2003, Hokama et al
     
  5. shannah

    shannah Senior Member

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    and another article at Prohealth written by Dr. Lapp - Included information on XMRV, now defunct, so ignore those references.


    http://www.prohealth.com/library/print.cfm?libid=15094

    Recommendations for CFS or FM patient facing surgery?

    by Dr. Charles Lapp, MD
    January 15, 2010

    Q: I will be having surgery to remove some fibroids soon, and neither my doctor nor the surgeon seem to know anything about ME/CFS or FM. I remember reading that there are things doctors can do to reduce possible complications and recovery time. Could you point me to something I can share with my doctors?

    A: The following information was developed to reduce the risk of surgical procedures for ME/CFS/FM patients. It is evidence-based, with sources, and is meant to be shared with the patient’s professional healthcare team.

    Recommendations for persons with ME/CFS (or Fibromyalgia) who are anticipating surgery

    Basically CFS is a disorder characterized by severe debilitating fatigue, recurrent flu-like symptoms, muscle pain, and neurocognitive dysfunction such as difficulties with memory, concentration, comprehension, recall, calculation and expression. A sleep disorder is not uncommon.

    • All of these symptoms are aggravated by even minimal physical exertion or emotional stress, and relapses may occur spontaneously.

    • Although mild immunological abnormalities (T-cell activation, low natural killer cell function, dysglobulinemias, and autoantibodies) are common in CFS, subjects are not immunocompromised and are no more susceptible to opportunistic infections than the general population.

    • [Recent research indicates antibodies to the XMRV retrovirus may be present in the blood of some CFS patients,* and] it is not recommended that the blood or harvested tissues of patients be used in others.

    • Intracellular magnesium and potassium depletion has been reported in CFS. For this reason, serum magnesium and potassium levels should be checked pre-operatively and these minerals replenished if borderline or low. Intracellular magnesium or potassium depletion could potentially lead to cardiac arrhythmias under anesthesia.

    • Up to 97% of persons with CFS demonstrate vasovagal syncope (neurally mediated hypotension) on tilt table testing, and a majority of these can be shown to have low plasma volumes, low RBC mass, and venous pooling. Syncope may be precipitated by cathecholamines (epinephrine), sympathomimetics (isoproterenol), and vasodilators (nitric oxide, nitroglycerin, a-blockers, and hypotensive agents). Care should be taken to hydrate patients prior to surgery and to avoid drugs that stimulate neurogenic syncope or lower blood pressure.

    • Allergic reactions are seen more commonly in persons with CFS than the general population. For this reason, histamine-releasing anesthetic agents (such as pentothal) and muscle relaxants (curare, Tracrium, and Mevacurium) are best avoided if possible. Propofol, midazolam, and fentanyl are generally well-tolerated.

    • Most CFS patients are also extremely sensitive to sedative medications - including benzodiazepines, antihistamines, and psychotropics - which should be used sparingly and in small doses until the patient’s response can be assessed.

    • Herbs and complementary and alternative therapies are frequently used by persons with CFS and FM. Patients should inform the anesthesiologist of any and all such therapies, and they are advised to withhold such treatments for at least a week prior to surgery, if possible. Of most concern are:
    Garlic, ginkgo, and ginseng (which increase bleeding by inhibiting platelet aggregation);

    Ephedra or ma huang (may cause hemodynamic instability, hypertension, tachycardia, or arrhythmia),

    Kava and valerian (increase sedation),

    St. John’s Wort (multiple pharmacological interactions due to induction of Cytochrome P450 enzymes),

    Echinacea (allergic reactions and possible immunosuppression with long term use).​
    • The American Society of Anesthesiologists recommends that all herbal medications be discontinued 2 to 3 weeks before an elective procedure. Stopping kava may trigger withdrawal, so this herbal (also known as awa, kawa, and intoxicating pepper) should be tapered over 2 to 3 days.

    • Finally, HPGA Axis Suppression is almost universally present in persons with CFS, but rarely suppresses cortisol production enough to be problematic. Seriously ill patients might be screened, however, with a 24-hour urine free cortisol level (spot or random specimens are usually normal) or Cortrosyn stimulation test, and provided cortisol supplementation if warranted. Those patients who are being supplemented with cortisol should have their doses doubled or tripled before and after surgery.

    Summary Recommendations

    1. Ensure that serum magnesium and potassium levels are adequate.

    2. Hydrate the patient prior to surgery.

    3. Use catecholamines, sympathomimetics, vasodilators, and hypotensive agents with caution.

    4. Avoid histamine-releasing anesthetic and muscle-relaxing agents if possible.

    5. Use sedating drugs sparingly.

    6. Ask about herbs and supplements, and advise patients to taper off such therapies at least one week before surgery.

    7. Consider cortisol supplementation in patients who are chronically on steroid medications or who are seriously ill.

    8. Relapses are not uncommon following major operative procedures, and healing is said to be slow but there are no data to support this contention.


    I hope that you have found these comments useful, and that they will serve to reduce the risk of surgical procedures.

    Yours truly,
    Charles W. Lapp, MD:
    Director, Hunter-Hopkins Center, P.A.
    7421 Carmel Executive Park Drive, Suite 320
    Charlotte, NC 28226
    Telephone (704) 543 9692 begin_of_the_skype_highlighting [​IMG](704) 543 9692 FREE end_of_the_skype_highlighting; Fax (704) 543-8547
    Website: www.drlapp.net
    - Assistant Consulting Professor at Duke University Medical Center
    - Diplomate, American Board of Internal Medicine
    - Fellow, American Board of Pediatrics
    - American Board of Independent Medical Examiners

    Bibliography
    (Rev 1/2005)

    Bates DW, Buchwald D, et al., “Clinical laboratory findings in patients with CFS,” 1995 Jan 9, Arch Int Med 155:97-103

    Klimas NG, Salvato FR, et al., “Immunologic abnormalities in CFS,” 1990 Jun, J Clin Microbiol 28(6): 1403-1410

    Caligiuri M, Murray C, Buchwald D, et al., “Phenotypic and functional deficiency of natural killer cells in patients with CFS,” 1987 Nov 15, J Immunol.;139(10):3306-13

    Cox IM, Campbell MJ, Dowson D, “Red blood cell magnesium and CFS,” 1991 Mar 30, Lancet 337: 757-760

    Burnet RB, Yeap BB, Chatterton BE, Gaffney RD, “Chronic fatigue syndrome: is total body potassium important?” Med J Aust. 1996 Mar 18;164(6):384

    Bou-Houlaigah I et alia, “The relationship between neurally mediated hypotension and the chronic fatigue syndrome,” JAMA 1995; 274:961-967

    Streeten D & Bell DS, “Circulating blood volume in CFS,” J of CFS 1998; 4(1):3-11

    Kowal K, Schacterele RS, Schur PH, Komaroff AL, DuBuske LM, “Prevalence of allergen-specific IgE among patients with chronic fatigue syndrome,” Allergy Asthma Proc. 2002 Jan-Feb;23(1):35-39

    Ang-Lee MK, Moss J, Yuan CS, “Herbal medications and perioperative care,” 2001 Jul 11, JAMA 286(2):208-216

    Demitrack MA, Dale JK, Straus SE et alia,”Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome,” J Clin Endocrinol Metab. 1991 Dec;73(6):1224-34
    ___
    * See “Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome,” Science, Oct 8, 2009.

    This information is reproduced with permission from the Vermont CFIDS Association website http://monkeyswithwings.com/vtcfids.html

    Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat, or cure any disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.
     
  6. Prosons

    Prosons

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    Thank you everyone, you are helpful and kind! :)

    Frank
     
  7. stridor

    stridor Senior Member

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    I should probably read the OR report from my operation. I think something happened.
    During the pre-op I received borderline distain and ridicule from the anesthetist, surgeon, and the Internist. None of them believed that I was Hg-tox, or that I had fatigue issues and the worst was the suggestion that I did not need hydrocortisone and that for some reason I was taking it optionally or recreationally.

    After the operation, everything changed. I got the HC without any guff. Their attitudes changed...and I wondered whether they got a wake-up call in the OR. After the operation I ended up with some complications. For one thing my kidneys shut down for a couple of days. This kind of bothered me because I used to have diabetes insipidus and worry about kidney function.

    I also got ileus which is a paralyzed small intestine = no ability to remove bile = poisons from the liver build up and enter circulation = impaired rationality. But I got through it.

    Anyway, I think that the information here is great. I wish that I had it when I went for my operation but am not convinced that it would have made any difference as it still requires a certain investment from the Drs that I did not have.
     
  8. Allyson

    Allyson *****

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    first I have heard of it - however it is well attested that EDSers require more anaesthetic often - though the reasons are not yet known - esp for dental procedures it seems so far

    Good luck

    ally
     
  9. ebethc

    ebethc Senior Member

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    Does anesthesia have a negative effect on me/cfs patients?
     
  10. Martial

    Martial Senior Member

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  11. xchocoholic

    xchocoholic Senior Member

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    It always takes me 3+ days to get it out of my system. I don't drive because I fall asleep off and on without notice and without feeling drowsy. Tc .. x
     
  12. minkeygirl

    minkeygirl Narcissism = lack of self awareness

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  13. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    Have a look here, and here.

    I am also merging this thread with an existing one on the subject, so that you post will now be here.
     
  14. zzz

    zzz Senior Member

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    Also, from The National CFIDS Foundation:
     
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