@LaurielL You always have such interesting posts My only caveats would be as follows: 1) Careful with the amyloid hypothesis link to Alzheimer's and then using that to hook in KP. The classical tau phosphorylation and beta secretase models of plaque formation and their relevance to ALZ are falling out of favor. I actually am pretty close to some of this research for professional reasons. Some recent conferences suggest we really don't know what is going on. The shift is towards earlier and better diagnosis. Treatment has been for the most part ... unsuccessful. 2) While ACAT may be relevant, there is again a population frequency problem. I think there must also be some sort of epigenetic factors. CFS / ME has a relatively abundant occupancy in the population (comparatively speaking). Homozygote ACAT is pretty darn rare. While heterozygote is too common. Maybe the genetics affects sensitivity but I still bet there are epigenetic factors. 3) I concur Martin Pall's work is more intriguing. Ironically though from personal experience every time I have tried to lower arginine intake (at diet level) or introduce lysine (I have high CMV and other titers), I always feel worse. As I have posted before I feel better eating four to five 1 oz serving of nuts a day. My diet is typically otherwise lysine heavy so the net effect is about equal balance. If I lower the nuts, I feel worse. If I add lysine I feel worse. Complicated to say the least. Who knows maybe it is more for me to do with the urea cycle and ammonia clearance. So many unknowns.