Hello all: I am looking for some guidance. I fell Ill with CFS/FIBRO/MS symptoms in 2009 after a long course of antibiotics for acne and taking CIPRO (I am well aware of Quinolone toxicity and beleive that it is playing a role in my health problems but feel that Cipro and a very stressful time in my life was the straw that broke the cammels back). On top of that I have depression, anxiety and panic and have dealt with pretty bad acne since I was 18 (Dairy and sugar free controls my acne but it has never truly cleared up). I am not disabled and manage to get by okay but my health challenges are really preventing me from living a normal life. I am a 25 year old male and for the past 2 years have been doing ozone saunas, eating a high plant based diet of nuts, seeds, quinoa, buckwheat, brown rice, tones of green vegetables, onions, garlic, no fruit except lemons and limes and red meat, chicken or fish a few times a week. I eat no sugar, dairy or gluten except on very and I mean very rare occasions. I have seen an alternative MD and am taking 20 mg of Cortef, 10mg DHEA and 60mg of Armour.I have worked on my gut health and feel it is in very good shape. And feel like I have detoxed quite a bit of the junk inside me. I take a digestive enzyme with every meal, chlorella, spirulina and probiotics. I also take magnesium, chromium and COQ10. All of this has helped me quite a bit but I have plateaued and then I stumbled onto MTHFR which I think may be the missing piece of the puzzle. My symptoms seem to be worse in winter especially the mental ones. 23andME results. VDR BSM: +/- VDR TAQ: +/- MAO A R297R: + MTHFR C677T: +/- MTHFR A1298C: +/- MTRR A66G: +/- MTRR H595Y: +/- MTRR K350A: +/- MTRR A664A: +/- BHMT-08: +/- CBS C699T: +/- SHMT1 C1420T: +/- My Symptoms: -Panic, anxiety, depression (worse in winter, tolerable in summer) -Fatigue, though not severe -Tinnitus occasionally -Raynauds -Numbness /tingling -Muscle twitching -Poor memory/focus -Brain fog/derealization -Acne (since I was 18) -Hair Loss (since I was 18) -Gynocymasteia (since I was 15) I have a family history of Depression, Alzhimers, Bipolar, Anxiety, Heart Disease and Stroke. I received my results and was not at all surprised that I had MTHFR, I was actually releived because It potenntally explains some of my problems. I thought I had COMT because I got very hyper and anxious when I took Phosphatidycholine, and aceytl-l-carnatine. I also experienced increased depression when taking Zinc and P5P. I am concerned about MTRR mutations as I have a lot of those and are wondering how concerned I should be as I realize B12 is extemnely important and wondering if this mutation caused a deficiency in B12 I am also conerned about the CBS pathway as I seem to tollerate sulfur well. I eat quite a high sulfur diet (onions, some garlic, broccoli, brussel sprouts) and at one point took MSM which I didn’t fell affected me negativly. I beleive I have a high intake of molybdenum as I eat a ton of sprouted Lentils and Mung Beans which are supposedly very high in molybdenum. Does it matter that I am +/- as opposed to +/+ and how should I go about treating the pathway. Also, any Ideas of why P5P could have caused depression or why Phosphatidycholine caused Anxiety? Is It possibly because I hadn’t addressed MTHFR at all? I would really like to begin treating the MTHFR MTRR as soon as possible but don’t want to cause any problems.Will I have to address CBS first? The CBS is waht confuses me quite a bit as I have educated myself pretty well on all of this but am looking for some guidance. If anyone can give me some solid guidance I would really appreciate it. Thanks a Million Andy PS if any more information is needed just ask.