makes it hard to know as cfs is generally an up and down illness as it is. I suppose a few things to look for is are your downs not as low as previously and are the amount of good days u r having are more then previously?? Other then those all i can suggest is get to the 6 month mark and reassess to see if u think its worth it. Its really the only way we have unless we can get tested for every dam thing. As dr lerner has found out, partially responders generally have bacterial co-infections going on as well. This is why i also mention the doxycycline too.