Hi Lotus, B12 will create a stronger reaction and possibly cause overmethylation so be prepared to lower your dose of B12 if necessary It just doesn't work that way. Healing can turn on at about 100mcg absorbed per day for most layers. Below that it's "iffy", not proportional. The curve shows that at about 10mcg there is a minute effectiveness that never really gets going the absorbed dose increases the effectiveness increases at an increasing rate, goes over the knee on the way up at a bit bellow 100mcg (estimated) and goes up very slowly after that. I would predict that in a well controled study that virtually nobody could distinguish between 250 mcg absorbed and 5000mcg absorbed on the basis of reactions. As for adenosylcobalamin, I would wait until you get the methyl b12, folinic acid, and methylfolate in place before adding it. If you take And I'm finding it most effective in a lot of people to microtitrate both AdoCbl and MeCbl with methylfolate for predictable results. Then, as soon as healing turns on, cease titration of those and bring everything else into balance before continuing. That way one doesn't bounce all over the place alternating back and fort on and off methyltrap and partial ATP block. Low potassium is a common and potentially lifethreatening effect of overmethylation and overdriving the methylation cycle so you might want to consider supplementing with potassium even if you are taking hydroxocobalamin. The percentage of hypokalemia with HyCbl is lower but is NOT a result of over methylation. It is the result of turming methylation on enough to start making a backlog of cells from years of delayed healing. With AdoCbl, MeCbl and l-methylfolate hypokalemia is a dependable and predictable occurance and ois the first sign of gneralized healing. Excessive potassium need as Dbkita pointed out can happen and is something else entirely different which does need to be identified. Capsules and tablets are not recommended for potassium supplementation because those can damage the stomach and GI tract. This warning applies to prescription time release forms of a non-disperable type that has 500mg in a single capsule/pill that can sit in a dissolving mass against the stomach causing tissue necrosis. It is not a hazzard of OTC capsules or fast dissolving low dose pills. But it is well worth warning. Also, don't take too much at a time. More smaller doses with a full gass of water are more effective and safer.