Hey guys this is my first post, but it's probably going to be long, please bear with me. I've experienced heavy brain fog, depression, derealization, chronic fatigue, etc, etc, yada, yada since I was 16-17 years of age. I'm now 28. I've always had anxiety, around the age of 14-15 I discovered I could temporarily silence it with alcohol. Soon there-after the other problems came. I tried to fix it by quitting drinking, exercise, etc, nothing helped and I would often go back to drinking as a way to feel better. This was obviously a terrible idea but it was the only time I felt any better, brain fog would even clear up at certain levels oddly enough. The main problem with my coping mechanism (besides the unknown pernicious anemia it was causing for over a decade) was that my hangovers would be so excruciatingly bad that I would often not be able to function for multiple days after a night of only a few drinks (4-6). I had tried different supplements throughout the years to no avail, including Jarrow 5000 mcg (that's microgram, there is 1000 micrograms in a mg, so please stop saying you take 5000mg I've been seeing that often and it's confusing/incorrect) methylcobalamin. I was eating them too quickly however, as I never noticed an improvement with them except for that the sores under my tongue I would occasionally get would disappear within minutes of taking it. Later on I decide to try a sublingual spray on a whim which contained about 500mcg per spray. I took it without noticing anything. One day after a visit from an old friend and a night of partying I woke up with a list of obligations and a hangover so bad I couldn't get out of bed. Out of desperation I tried everything to make it feel better. At some point I sprayed probably 10 sprays of that methyl b12 under my tongue and held it for as long as possible before my saliva washed it away. Within about 45 minutes I was playing with my dog and running around the house with him, I was still hungover but I like to refer to it as "a normal person hangover". Now my interest in mb12 was piqued. I studied, learned about intrinsic factor, how I destroyed it with drinking, etc, etc. I needed to find an alternative way, a more bio-available way, of taking this without having to spend exorbitant amounts of money and requiring prescriptions/etc. So I researched the best alternatives to injection. I discovered the nasal spray method, which was the first time I noticed improvements outside of sublingual dosing. Just an FYI, not all sublingual sprays will work as a nasal spray, many contain chemicals that will hurt and burn your sinuses. After taking it for a few days at 1500mcg per nostril a day my hands and feet quit being cold all of the time, I started feeling some emotions and even small glimmers of excitement. I realized this could continue to get better and that the damage may not all be permanent. Next up on the best ways of taking mb12 without a needle: inhalation. First, you may want to read this research on b12 inhalation and how it's almost as effective as injections. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248818/pdf/tacca00127-0101.pdf) Also how none is excreted through urine like a sublingual or oral dose, instead it's pretty much all used except for what isn't captured in your lungs. As little as 100mcg a day inhaled is highly effective and comparable to injections. Personally I inhale about 325mcg a day for various factors including that I don't know how much has broken down to hydrocobalamin by the time it's dissolved in water in a lab to the time I'm evaporating it, also due to the fact that b12 isn't toxic in any dose, also I like to over due everything that I safely can. To do this you'll need an atomizer, which thanks to the electronic cigarette revolution you can find in most gas stations or "vape shops" around or just online for really cheap. I suggest one with a tank or 'clearomizer' and a decent size battery. Next you just need some pure mb12 in some vegetable glycerin (a safe vaping chemical which is in electronic cigarette liquid) and you're off. Make sure you keep it all hidden from light, that is the liquid, and your ecigarette tank, I use electric tape on my glass tank. The research article suggests you do a hard exhale, then a slow deep inhale with the vaporizer, and then hold as long as you can, and then exhale slowly through the nose. This technique works wonders. What I could not ever achieve with weeks of sublingual and nasal dosing I get in 15 minutes of inhalation. With my mix half a tank (.75ml) is 325mcg and I can inhale it all day keeping my plasma levels completely saturated. After two days of doing this I feel the mb12 effects constantly now, it must have built up in my liver already. I now only inhale it in the mornings. You will notice (if you're mb12 deficient) the effects almost immediately. I started feeling dizzy like I do when I take a TON of mb12 sublingually/nasal. The first time I inhaled it after about 5-10 minutes I felt like I had taken 500,000mcg of mb12 sublingually (speculation as I've never taken that much). I like to imagine the feeling I get is comparable to what I'd feel if I had a b12 injection, but I can't say for sure as I've never had one. After discovering this I decided to search online for others who may find this information useful and after two days of waiting for my account to be accepted here it is! Here again, is the research on the subject: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248818/pdf/tacca00127-0101.pdf Feel free to ask me any questions, I am in the beginning stages of methylation so I may not have all of the answers. Most of what you need will be in the research link above. Also I'm not a scientist, I did not do this study, and I cannot guarantee the safety of it. Hell I'm not even suggesting it's safe, although the research article plainly does. All I can say for sure is that I've noticed no ill-effects on my lungs or lung-capacity since starting this and it seems to work about 100x more than sublingual pills and 10x more than nasal sprays, once again my subjective/speculative opinion. Enjoy.