Hi, I started Fredd's MP a couple of years ago and had to abort around the three month mark....and it's happening again, although for different reasons, at pretty much the same three month point :-( I purposefully took it easy this time with a view to building up, and this was my daily regime for two months: Breakfast followed by one general RDA multivit that I've been taking for years (Carlson Mini Multi) One 100mcg NOW Selenium tablet mid-morning (taken for years) Half a Thorne Basic B capsule (split into another veggie cap) late afternoon One magnesium malate tablet at bedtime (again, I've been taking these for years) So basically all I added to my daily regime as a gentle starting off point was the half a Thorne Basic B Complex, which is a co-enzyme formula. As a backgound, I have CFS/ME and have been getting slowly worse over these past four years after a pretty sustained and nasty period of personal stress. Anyway, just like the last time I tried coenzyme B Complex, I experienced noticeable improvements in my mood, energy and post-exertional malaise. Nothing like a cure or a quick fix of course but improvements nonetheless and I'm loathe to pack this in. HOWEVER, around the two month mark I started to notice slight swelling in my lower legs, the first few inches above my ankle. This got steadily worse and apart from being uncomfortable and my socks leaving deep, bruised indentations, I became worried that I had some major issue like heart failure or something! Only the fact this came on whilst taking active Bs has reassured me (*a little) that this is a coincidence and is related to my methylation, or a possible intolerance to something. SO, reading up on the web as to what might be causing this I came up with nothing except the usual suspects of heart failure and furred-up arteries etc. Not pleasant reading! On here though, Phoenix Rising, after reading for hours & hours, I did see some slight mention of edema and I also noticed that low potassium can cause it. Therefore I started munching bananas, I ate approx four per day whilst continuing to take all my supplements. The leg swelling improved a little but is still hanging around and on some days it is quite bad. SO, alongside the bananas I started to add 1/4 of a Solgar metafolin tablet to my daily regime thinking that I was under/over methylating but I haven't got a clue. This seemed to have no positive effect other than making me feel more fatigued, so I added half a Solgar sublingual MB12 lozenge (half of 1000mcg). Again this has had no positive effect on my lower leg swelling. So I'm lost now. I haven't a clue on which supplement to cut back, which to increase the dose, or indeed what to add next. I'm loathe to quit taking the active Bs as they are definitely helping, but I can't stand this lower leg swelling/edema. It will end up making me stop (which I indeed did for a few days with no real improvement). Any ideas? I'm fairly sure that if I stop all the Bs and folate that eventually everything will return to normal but I'm looking for some advice on how to keep the wheels turning.