Hello, I am going trough lyme treatment right now and I have a lot of herxheimer reactions. I have been trying to get my methylation going so my body can get rid of the toxins. But all attempts failed because all these supplements wash away my antidepressant. I go into acute withdrawl. I've tried lactoferrin (which helps with glutathione) B12 extreme (from prohealth with 4 kinds of B12 including high dose methylcobalamin) and folinic acid (did not have the courage yet to try methafolate). Something strange is going on there as the withdrawl seems to be catalized at te moment I eat something with soy/lecitin/soylecitin in it. Well, I've seen lecitin in methylation protocols so it might not be that strange, but I would not expect much lecitin in some cookies. I've searched the internet for methylation and prescription drugs. I found information about being able to stop some prescription medications, but nothing about needing more of them. I really need my antidepressant. I use Mirtazapine. I have increased the dose from a very low dose of 7,5 mg, to a 'normal' dose of 30 mg. But it does not help! When I take one of these supplements I get a lot of fasciculations over my whole body and I get all symtpoms of withdrawl. After two days my mood drops from normal to very depressed. It does not help to take extra mirtazapine when I feel the withdrawl symptoms. I need to wait till the fasciculations are over before it will start working again. If I stop al these supplements my mood recovers within a few days. But I need to be careful with the lecitin for a while. Does this sounds familiar to anyone? Does this sound like overmethylation? I was very sensitive to medication before. That is why I used such a low dose of mirtazapine. It makes sense to me that if you stimulate the detox pathways, you also stimulate the metabolism of prescription drugs. But I cannot find information on this. My testresults on MTHFR were: 1298A/C high activity 677C/T moderate activity I don't know what this means. Thanks!