I looked at my 23andme dna data and picked out those that also appear on the Yasko panel, which as i understand it, is mainly (entirely?) about the methylation cycle. This post helped me do it, but I didnt want to hijack that thread, so I started this one instead. The outcome of this little exercise is that these are my three most dodgy genes: Rs6323 - MAO-A R297R +/+ (T) MTRR A66G +/+ (GG) MTRR-11 A664A +/+ (AA) Im going to try and look at each in turn, starting with Rs6323 - MAO-A R297R +/+ (T) in this thread. This is the wikipedia article on MAO-A: http://en.wikipedia.org/wiki/Monoamine_oxidase_A It talks about Brunner syndrome. Is that relevant? It also talks about inhibitors at the bottom, but I dont yet understand, does a T mean that I have LOW or HIGH levels of the related MAO-A enzyme? Looking at the heartfixer site, it seems to be saying that the enzyme that this gene expresses is supposed to turn Serotonin into HIAA - which I think is this stuff: http://en.wikipedia.org/wiki/5-Hydroxyindoleacetic_acid And it says that you pee this stuff out - so presumably that means this is how your body gets rid of serotonin when its done with it. In turn that seems to suggest that too much MAO-A and you break down too much serotonin, and too little MAO-A and you end up with too much. Well, I welcome anyones thoughts or knowledge on this.