My legs suddenly don't hurt as if I just ran a marathon and am coming down with the flu. Could that be valtrex all ready? I took one (gram) pill Saturday, then two Sunday and Monday. I am supposed to take 3 gram pills per day, but just can't make myself gag down that many yet. Does Valtrex affect the muscles in any way? The only thing that has been added in the last two weeks so far is Zyrtec I went from 1 to 2 pills per day, and Zantac 2 per day. Also 4000 mg vit D. Is the happy legs from Valtrex? Or the other pills? Also, I think the dr is switching to 500 mg pills so they will be easier to swallow. Although that has me taking 6 pills per day, but better than trying to vomit at work!