Per Wikipedia: "cholinesterase" breaks up (destroys) acetylcholine by turning acetylcholine into acetic acid and choline. And: "cholinesterase inhibitors" prevent cholinesterase from breaking up (destroying) acetylcholine. Nightshade foods are "cholinesterase inhibitors". Therefore, eating them would logically INcrease the levels of acetylcholine in the body. In other words, nightshade foods should RAISE the levels of acetylcholine in the body. RELATION TO THE GUT: Acetylcholine is needed for enough gut motility - I'm talking to people who have too-slow gut motility. Ordinary constipation people need not apply. This thread is for people with slow motility only, not helped by all the "wonderful" remedies for regular constipation that do nothing for slow gut motility. People with slow gut motility (NO, this is NOT the same thing as constipation) might not have enough acetylcholine in their guts doing what acetylcholine is supposed to do there: speed up gut motility. Those people "might" get some help with this slow-motility problems by eating more nightshade foods, as long as they don't have the type of joint problems that some people get from nightshades. The friggin internet is rife with misconceptions. I just saw a site on which people said nightshades CAUSED their slow gut motility, erroneously stating that it must because they are inhibitors of cholinesterase. Wrong. that cannot be the reason, per the above logic. Nightshades may be causeing that individual person slower motility for some other reason unique to that person, it cannot simply be "due to being an inhibitor of cholinesterase"