Hi folks: I've been intending to start a thread on gastroparesis also known as "delayed stomach emptying" and on colonic inertia for awhile. Both of these GI situations are often a part of POTS and dysautonomia and mitochondrial disease and so of course, found in CFIDS as well. Not being able to eat or elminate are very difficult problems to live with and can even, when very severe as my case has been, be life-threatening. Symptoms of GP include a feeling of fullness even on eating a tiny bite. One can have zero appetite—in my case I never even get hungry, my stomach muscle doesn't work well enough to get hungry. Or sometimes there is appetite but there may be nausea when one eats. There is a simple test for diagnosing gastroparesis which is called the "stomach emptying test." You eat radioactive scrambled eggs and then have a series of x-rays. My stomach only worked at 7% of normal when I first became acutely ill and the situation was life threatening and I had to be on nothing but tiny amounts of liquid nutrition. If you have severe constipation but usual remedies that work in healthy people such as increased fluids and increased fiber actually make things much worse, then you may well have a colon "motility" problem. Which means the colon's smooth muscle is not able to function well. The best simplest test for colonic inertia is called Sitz marker test. You swallow a capsule with little markers and then have a series of x-rays each day as they travel through the colon. The gastroparesis diet which can also help with colonic inertia as well is usually high protein (because calorie restriction is so limited) and low fat (fat slows motility) and low fiber (if there is a motility problem fiber can actually SLOW motility whereas in a healthy person it would speed it up.) Often one has to be on liquid nutrition product supplements to reduce the overall quantity of food/fiber eaten. There are various drugs that can be used for GP though all have some side effects, there is a good safe drug that can help with colonic inertia (Miralax) and a good website for further information on both of these conditions is www.gpda.org. I've been through every single GI test in the book and many experimental ones as well. Hope this info is of help to others.