Somebody once said on this forum that we PWC's are a breed apart. If the rest of people in the world look like horses then we would look like zebras. We have to be extra careful about the drugs and supplements we take, how much exercise we take, how much rest we have to take and even how much social interaction, in order to cope in the various stages of what is called, attempting to get back to 'normal functioning'. This often makes us in our eager and early endeavors to get back to 'normal functioning', take stuff we, or our doctors know not a lot about, particularly in the world of minerals such as magnesium. In my early days of this disease several years ago, I took on board the then current advice to have regular Magnesium flake baths, as everbody knew that "all PWC's have a magnesium shortage". All went well for a while and then I crashed very badly. It wasn't till investigating the effect that increased magnesium levels can have on other body minerals and the symptoms that can happen,to people like us (Zebras) , that I was able to piece together what had happened. Most of us know that Calcium must be balanced with Magnesium, but there are other minerals that Mg must be balanced with in the body to prevent out of balance symptoms. This is a mineral wheel diagram (on the left), showing the various interactions between Magnesium and other minerals including the heavy metals Lead(Pb) and Cadmium(Cd). On the right is the mineral wheel showing Magnesium interactions with vitamins. http://www.traceelements.com/docs/Magnesium Wheels.pdf The Sodium(Na) and Potassium(K) levels are particularly crucial for us, because these electrolytes are controlled by the adrenals and most of us have adrenal fatigue, which means we can have lower and usually more unstable levels of (Na) and (K) than normal, causing lower blood pressure. (Some people have only low Sodium or Potassium, not both). From the diagram it is clear that increasing magnesium is going to make the (Na) and (K) levels even lower,which will make the adrenals more unstable, lowering BP even more, as well as thyroid function through lower (K) Whilst going through this 'double whammy' energy reduction, the elevated magnesium can also bind to the heavy metals, lead(Pb) and cadmium(Cd) moving them out of the tissues into the bloodstream and organs increasing brain fog, ,as well as heart palpitations through the lower potassium(K). This pretty well sums up all the symptoms I was experiencing. In my ignorance of those days,whilst putting up with these symptoms I thought I was 'detoxing'! The reason I mentioned this is more people seem to be taking magnesium through nebulizers and transdermal Magnesium oil and its easy to get into the habit of ingesting too much. I wouldn't worry if you have been taking your present dose for a long while and have no adverse symptoms. If you really think you are going to increase Mg levels, my advice is to start off low and increase slowly, monitoring symptoms and increasing electrolytes, Sodium and Potassium as necessary along with the other minerals shown. Dr Sircus, who seems to major in magnesium oil, says people who have Hypothyroidism or Addison's Disease should avoid high intakes of magnesium. We may not have full blown Addison's but some of us could be classified as 'Addison's Lite' Most of the people without CFS/ME ( Horses), can get away with higher intakes of magnesium because of their higher BP and sodium levels, in fact Mg will help them if they need to reduce their sodium and high BP. However, remember we are zebras not horses, http://traceelements.com/Docs/The Nutritional Relationships of Magnesium.pdf . .