Hi Freddd; Yes, I read the paper, thanks for bringing it to us...excellent. I've tried adenosylcobalamin off and on for several years now. I first tried it unknowingly, when source naturals added it to its sublingual 'coenzyme' B complex. At that time, I still had alot of nerve inflammation. I found it to be irritating to my nerves, especially in the mouth. ( Before that, I gave some to my MIL, she returned it to me, describing it as, 'it makes my gums hurt'.) I've tried the source naturals brand, country life brand, and the anabol naturals brand. I've still had inflammation from them, but the anabol naturals brand was the least problematic. I may retry in the future. It doesn't make sense, when the studies show otherwise, but I can't deny my repeated negative results. They were too painful. OF course, things will change, but for now, the MeCbl and HyCbl is my best anti-inflammatory combo. I suspect that the B12 deficiency and folate trap may have been one of the causes of my auto-immune conditions.