LDN is one of the treatments that I started on pretty quickly after being diagnosed with CFS. When I first titrated up to the 4.5mg dose I felt absolutely amazing. My sleep was incredibly refreshing, my brain fog was gone, I was very energetic and motivated, and at work I was really engaged and practically dancing while working at the computer. Over time the effects became less obvious though. Now two years later I continue to take it, but it's not clear that it gives me any benefits. If I miss a dose, or even if I take a break for a whole week, I don't notice any difference. My doctor still seems to think that it's important that I stay on it though. What are your experiences? Does it still seem like a clear win to you?